Helicobacter pylori infection and gastric cancer

被引：18

作者：

Sugiyama T. ^{[1
]}

Asaka M. ^{[1
]}

机构：

[1] Department of Gastroenterology, Hokkaido University, Graduate School of Medicine, Kita-ku, Sapporo 060-8638, North 15

来源：

Medical Electron Microscopy | 2004年 / 37卷 / 3期

关键词：

Apoptosis; Cag pathogenicity island; CagA; Gastric cancer; H; pylori; Hummingbird morphology; Proliferation; Type IV secretion machinery system;

D O I：

10.1007/s00795-004-0250-7

中图分类号：

学科分类号：

摘要：

Helicobacter pylori infection has an association with histological gastritis, gastric atrophy, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma in the stomach. Gastric cancer occurs in only a minority of infected individuals, however. Such clinical diversities are caused by variations of H. pylori pathogenicity, host susceptibility, environmental factors, and interactions of these factors. By three prospective epidemiological studies, the International Agency for Research on Cancer, World Health Organization (IARC/WHO) concluded in 1994 that H. pylori had a causal linkage to gastric carcinogenesis and is a definite carcinogen in humans. In addition, the Mongolian gerbil model with or without low-dose chemical carcinogens demonstrated that H. pylori infection could develop into gastric cancer. The experimental studies have elucidated that virulence factors of H. pylori have an interaction with gastric epithelial cell signaling related to carcinogenesis. The cag pathogenicity island (cagPAI) is a major virulence gene cluster and codes the type IV secretion machinery system, forming a cylinder-like structure. The CagA protein is translocated into target cells via this secretion system and induces a hummingbird morphology, growth factor-like effect. The other gene products are probably translocated into target cells and accelerate cellular proliferation and apoptosis. Understanding the molecular mechanism of the interaction between H. pylori and gastric epithelial cells will provide us with a new strategy for effective prevention of the development of gastric cancer induced by H. pylori infection. © The Clinical Electron Microscopy Society of Japan 2004.

引用

页码：149 / 157

页数：8

共 54 条

[1]

Helicobacter pylori in peptic ulcer disease, JAMA, 272, pp. 65-69, (1994)

[2]

Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report, Gut, 41, pp. 8-13, (1997)

[3]

Lam S.K., Talley N.J., Helicobacter pylori consensus. Report of the 1997 Asian Pacific Consensus Conference on the management of Helicobacter pylori infection, J Gastroenterol Hepatol, 13, pp. 1-12, (1998)

[4]

Asaka M., Satoh K., Sugano K., Sugiyama T., Takahashi S., Fukuda Y., Ohta H., Murakami K., Kimura K., Shimoyama T., Guidelines in the manegement of Helicobacter pylori infection in Japan, Helicobacter, 6, pp. 177-186, (2001)

[5]

Parsonnet J., Friedman G.D., Vandersteen D.P., Chang Y., Vogelman J.H., Orentreich N., Sibley R.K., Helicobacter pylori infection and risk of gastric carcinoma, N Engl J Med, 325, pp. 1127-1131, (1991)

[6]

Nomura A., Stemmermann G.N., Chyou P.H., Kato I., Perez-Perez G.I., Blaser M.J., Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii, N Engl J Med, 325, pp. 1132-1136, (1991)

[7]

Forman D., Newell D.G., Fullerton F., Yamell J.W., Stacey A.R., Wald N., Sitas F., Association between infection of Helicobacter pylori and risk of gastric cancer, Br Med J, 302, pp. 1302-1305, (1991)

[8]

Lauren P., The two histological main type of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma, Acta Pathol Microbiol Res, 64, pp. 31-39, (1965)

[9]

Uemura N., Okamoto S., Yamamoto S., Matsumura N., Yamaguchi S., Yamakido M., Taniyama K., Sasaki N., Schlemper R.J., Helicobacter pylori infection and the development of gastric cancer, N Engl J Med, 345, pp. 784-789, (2001)

[10]

Yamagata H., Kiyohara Y., Aoyagi K., Kato I., Iwamoto H., Nakayama K., Shimizu H., Tanizaki Y., Arima H., Shinohara N., Kondo H., Matsumoto H., Fujishima M., Impact of Helicobacter pylori infection on gastric cancer incidence in a general Japanese population: The Hisayama study, Arch Intern Med, 160, pp. 1962-1968, (2000)

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