Association of diabetes and hepatitis C infection: Epidemiologic evidence and pathophysiologic insights

被引：54

作者：

Bahtiyar G. ^{[1
]}

Shin J.J. ^{[1
]}

Aytaman A. ^{[1
]}

Sowers J.R. ^{[1
]}

McFarlane S.I. ^{[1
]}

机构：

[1] Div. Endocrinol. Diabet./Hypertens., SUNY-Downstate Health Science Center, Brooklyn, NY 11203

来源：

Current Diabetes Reports | 2004年 / 4卷 / 3期

关键词：

Chronic Hepatitis; NASH; Primary Biliary Cirrhosis; Alcoholic Liver Disease; Nonalcoholic Fatty Liver Disease;

D O I：

10.1007/s11892-004-0023-7

中图分类号：

学科分类号：

摘要：

Up to one third of patients with chronic hepatitis C virus (HCV) develop type 2 diabetes mellitus (DM). This prevalence is much higher than that observed in the general population, and in patients with other chronic liver diseases such as hepatitis B virus, alcoholic liver disease, and primary biliary cirrhosis. Further, HCV seropositivity in patients with DM appears to be higher than in the general population. Post-liver transplantation DM also appears to be higher among patients with HCV. In this article, we review the epidemiologic association between HCV and DM, highlighting the most recent pathophysiologic insights into the mechanisms underlying this association. Copyright © 2004 by Current Science Inc.

引用

页码：194 / 198

页数：4

共 43 条

[1] Williams I., Epidemiology of hepatitis C in the United States, Am. J. Med., 107, 6 B, (1999)
[2] Alter M.J., Epidemiology of hepatitis C in the West, Semin. Liver Dis., 15, pp. 5-14, (1995)
[3] Shakil A.O., Conry-Cantilena C., Tedesschi V., Et al., Volunteer blood donors with antibody to hepatitis C virus: Clinical, biochemical, virologic, and histologic features. The Hepatitis C Study Group, Ann. Intern. Med., 123, pp. 330-337, (1995)
[4] Gumber S.C., Chopra S., Hepatitis C: A multifaceted disease, Ann. Intern. Med., 123, pp. 615-620, (1995)
[5] Luo J.C., Hwang S.J., Li C.P., Et al., Clinical significance of serum auto-antibodies in Chinese patients with chronic hepatitis C: Negative role of serum viral titer and genotype, J. Gastroenterol. Hepatol., 13, pp. 475-479, (1998)
[6] Donovan Jr. D., Epidemiology of diabetes and its burden in the world and in the United States, Principles of DM, pp. 107-121, (2002)
[7] Mokdad A.H., Ford E.S., Bowman B.A., Et al., The continuing increase of diabetes mellitus in the US, Diabetes Care, 24, (2001)
[8] Allison M.E., Wreghitt T., Palmer C.R., Alexander G.J., Evidence for a link between hepatitis C infection and diabetes mellitus in a cirrhotic population, J. Hepatol., 21, pp. 1135-1139, (1994)
[9] Mehta S., Brancati F., Sulkowski M., Thomas D., Et al., Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States, Ann. Intern. Med., 133, pp. 592-599, (2000)
[10] Fraser G.M., Harman I., Porath A., Et al., Diabetes mellitus associated with chronic hepatitis C but not chronic hepatitis B infection, Isr. J. Med. Sci., 32, pp. 526-530, (1996)

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