The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection

被引：29

作者：

Ozaki H. ^{[1
]}

Hiraoka T. ^{[2
]}

Mizumoto R. ^{[3
]}

Matsuno S. ^{[4
]}

Matsumoto Y. ^{[5
]}

Nakayama T. ^{[6
]}

Tsunoda T. ^{[7
]}

Suzuki T. ^{[8
]}

Monden M. ^{[9
]}

Saitoh Y. ^{[10
]}

Yamauchi H. ^{[11
]}

Ogata Y. ^{[12
]}

机构：

[1] Department of Surgery, National Cancer Center Hospital, 1-1 Tsukiji 5-Chome, Chuo-ku

[2] First Department of Surgery, Kumamoto Univ. School of Medicine, 1-1-1 Honjo

[3] First Department of Surgery, Mie University Faculty of Medicine, 2-174 Edobashi

[4] First Department of Surgery, Tohoku Univ. School of Medicine, 1-1 Seiryo-cho, Aoba-ku

[5] First Department of Surgery, Yamanashi Medical University, 1110 Tamaho

[6] Second Department of Surgery, Kurume Univ. School of Medicine, 67 Asahi-machi

[7] Second Department of Surgery, Nagasaki Univ. School of Medicine, 7-1 Sakamoto-machi

[8] Second Department of Surgery, Yamaguchi Univ. School of Medicine, 1144 Kogushi, Nishi-ku

[9] Second Department of Surgery, Osaka University Medical School, 2-2 Yamadaoka

[10] First Department of Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku

[11] Department of Surgery, Sendai National Hospital, 2-8-8 Miyagino, Miyagino-ku

[12] Department of Surgery, Tochigi Cancer Center, 4-9-13 Yonan

来源：

Surgery Today | 1999年 / 29卷 / 1期

关键词：

Lymph node metastasis; Pancreatectomy; Pancreatic adenocarcinoma; Perineural invasion; Prognostic factor;

D O I：

10.1007/BF02482964

中图分类号：

学科分类号：

摘要：

To investigate the prognostic factors of pancreatic cancer, a retrospective analysis of 193 patients who underwent curative resection was conducted. Of the 193 patients, 38 (20%) survived for more than 5 years, the 5-year survival rates for stages I, II, III, and IV disease being 41%, 17%, 11%, and 6%, respectively. According to a multivariate analysis, lymph node metastasis, intrapancreatic perineural invasion, and portal vein invasion were significant prognostic factors. Subsequently, a subgroup analysis concerning nodal metastasis and intrapancreatic perineural invasion was performed in 126 patients with records of these histological findings. In the group of patients without nodal metastasis, the 5-year survival rate for those without perineural invasion was 75%, whereas that for those with perineural invasion was 29%, the difference in survival of these subgroups being significant (P < 0.02). In the group of patients with nodal metastasis, the 5-year survival rate for those without perineural invasion was 17%, while that for those with perineural invasion was 10%. The most favorable 5-year survival of 89% was observed in the subgroup of patients with stage I disease without perineural invasion. Thus, pancreatic adenocarcinoma categorized by the combination of these independent types of biological behavior showed 5- year survival rates ranging from very high to low, indicating that these two factors play an important role in the prognosis of this disease.

引用

页码：16 / 22

页数：6

共 25 条

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