Immune cell-mediated liver injury

被引：37

作者：

Corazza N. ^{[1
]}

Badmann A. ^{[1
]}

Lauer C. ^{[1
]}

机构：

[1] Division of Immunopathology, Institute of Pathology, University of Bern, 3010 Bern

来源：

Seminars in Immunopathology | 2009年 / 31卷 / 2期

关键词：

Fas ligand; Liver disease; TNF family members; Tumor necrosis factor-α (TNFα); Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL);

D O I：

10.1007/s00281-009-0168-1

中图分类号：

学科分类号：

摘要：

Liver diseases represent an important cause of morbidity and mortality in the world. Death of hepatocytes and other hepatic cell types is a characteristic feature of several forms of liver injury such as cholestasis, viral hepatitis, drug- or toxin-induced injury, and alcohol-induced liver damage. Moreover, irrespectively of the reason, liver injury seems to be facilitated by similar immune effector mechanisms common to these various liver diseases. Indeed, common immune effector mechanisms may explain the high prevalence of cirrhosis and cancer development in most forms of liver disease. Improved understanding of the immune cell-mediated mechanisms involved in hepatocyte cell death could be beneficial for the development of common therapeutic strategies against different forms of liver diseases. In this review, we will discuss novel findings on the role of different immune cells in liver disease and immune cell-induced death executioner mechanisms involved in hepatocyte cell death. © 2009 Springer-Verlag.

引用

页码：267 / 277

页数：10

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