An opium alkaloid- papaverine ameliorates ethanol-induced hepatotoxicity: Diminution of oxidative stress

被引：40

作者：

Chandra R. ^{[1
]}

Aneja R. ^{[2
]}

Rewal C.

Konduri R.

Dass S.K.

Agarwal S.

机构：

[1] Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi

[2] Department of Chemistry, University of Delhi

来源：

Indian Journal of Clinical Biochemistry | 2000年 / 15卷 / 2期

关键词：

Ethanol; Glutathione; Lipid Peroxidation; Oxidative Stress; Papaverine;

D O I：

10.1007/BF02883745

中图分类号：

学科分类号：

摘要：

In this communication, we show the modulatory potential of papaverine, an opium alkaloid and a well known vasodilator agent on the ethanol-induced hepatic oxidative stress in male Wistar rats. Ethanol treatment (50% v/v) enhanced lipid peroxidation significantly accompanied by a decline in the activities of glutathione peroxidase (G-Px), glutathione reductase (GR) and depletion in levels of hepatic glutathione (GSH). Ethanol administration increased hepatic lutathione-s-transferases (GST). Enhanced lipid peroxidation induced by ethanol was significantly reduced when papverine was coadministered (P<0.05). In addition, the depleted levels of glutathione and inhibited activities of G-Px and GR recovered significantly (P<0.05) levelling off to control values on co-exposure. Papaverine (200 mg/kg bw) effectively antagonised the ethanol-induced lipid peroxidation and impaired glutathione levels and glutathione dependent enzyme systems. Our results suggest that papaverine is an effective chemopreventive agent in the liver and may suppress the ethanol-induced hepatotoxicity.

引用

页码：155 / 160

页数：5

共 19 条

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