What’s new in β-lactamases?

被引：30

作者：

Patricia A. Bradford

机构：

[1] Wyeth-Ayerst Research,

来源：

Current Infectious Disease Reports | 2001年 / 3卷 / 1期

关键词：

Cephalosporin; Lactam; Antimicrob Agent; Clavulanic Acid; AmpC;

D O I：

10.1007/s11908-001-0054-z

中图分类号：

学科分类号：

摘要：

β-lactamases continue to be the leading cause of resistance to β-lactam antibiotics, among gram-negative bacteria. In recent years, both the incidence and the prevalence of extended-spectrum β-lactamases, inhibitor-resistant β-lactamases, AmpC-type enzymes, and both metallo-carbapenemases and nonmetallo-carbapenemases have increased. These β-lactamases provide resistance to oximino-cephalosporins, β-lactam/β-lactamase inhibitor combinations, cephamycins, and carbapenems, respectively. Strains expressing these β-lactamases will generate a host of therapeutic challenges as we begin the 21st century.

引用

页码：13 / 19

页数：6

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