The role of C-reactive protein in cardiovascular disease risk

被引：67

作者：

Albert M.A. ^{[1
]}

Ridker P.M. ^{[1
]}

机构：

[1] Cardiovascular Division, Brigham and Women's Hospital, Harvard University Medical School, Boston, MA 02115

来源：

Current Cardiology Reports | 1999年 / 1卷 / 2期

关键词：

Unstable Angina; Coronary Artery Disease Risk Factor; Recurrent Coronary Event; Secondary Preventive Therapy; European Concert Action;

D O I：

10.1007/s11886-999-0066-0

中图分类号：

学科分类号：

摘要：

The genesis of an atherosclerotic plaque depends on interplay of cellular components of the immune system such as monocytes, cytokines, and cell adhesion molecules with lipids, platelets and endothelial cells. Thus, inflammation may play a pivotal role in the propagation of coronary artery disease. Several reports have linked inflammation and cardiovascular risk, particularly a novel acute inflammatory peptide, C-reactive protein (CRP), with future risk of coronary events independent of the traditional coronary artery disease risk factors. To this end, many studies suggest that CRP may be used as a marker of sub-clinical atherosclerosis and cardiovascular risk. Specifically, CRP has been positively linked to future cardiovascular events in healthy women, healthy men, elderly patients, and high-risk individuals. In addition, reports have shown associations between CRP and peripheral vascular disease and stroke. Furthermore, preliminary data suggest that the relative efficacy of secondary preventive therapies such as statin drugs and aspirin may depend on the individual patient's baseline CRP level. Copyright © 1999 by Current Science Inc.

引用

页码：99 / 104

页数：5

共 34 条

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