NOS1AP in schizophrenia

被引：33

作者：

Brzustowicz L.M. ^{[1
]}

机构：

[1] Department of Genetics, Rutgers University, Piscataway, NJ 08854

来源：

Current Psychiatry Reports | 2008年 / 10卷 / 2期

关键词：

Schizophrenia; Canadian Family; Susceptibility Change; Schizophrenia Susceptibility; International HapMap Consortium;

D O I：

10.1007/s11920-008-0027-0

中图分类号：

学科分类号：

摘要：

NOS1AP is an attractive candidate gene for schizophrenia susceptibility. Linkage and association studies from multiple samples drawn from different populations indicate that a schizophrenia susceptibility gene is located in the region of chromosome 1 containing NOS1AP. Increased NOS1AP expression is observed in post-mortem samples from individuals with schizophrenia. NOS1AP binds to neuronal nitric oxide synthase and synapsin, other candidate genes for schizophrenia, and may disrupt signal transduction through the N-methyl D-aspartate receptor complex, leading to hypofunctioning of that system. In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：158 / 163

页数：5

共 43 条

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