Functional genomics in the mouse

被引：13

作者：

Perkins A.S. ^{[1
]}

机构：

[1] Department of Pathology and Molecular, Cellular, Developmental Biology, Yale University, New Haven, CT 06520-8023

来源：

Functional & Integrative Genomics | 2002年 / 2卷 / 3期

关键词：

Developmental biology; Genomics; Mutagenesis;

D O I：

10.1007/s10142-002-0049-3

中图分类号：

学科分类号：

摘要：

The mouse is the premier genetic model organism for the study of human disease and development. With the recent advances in sequencing of the human and mouse genomes, there is strong interest now in large-scale approaches to decipher the function of mouse genes using various mutagenesis technologies. This review discusses what tools are currently available for manipulating and mutagenizing the mouse genome, such as ethylnitrosourea and gene trap mutagenesis, engineered inversions and deletions using the cre-lox system, and proviral insertional mutagenesis in somatic cells, and how these are being used to uncover gene function. © Springer-Verlag 2002.

引用

页码：81 / 91

页数：10

共 65 条

[1]

Anderson K.V., Finding the genes that direct mammalian development. ENU mutagenesis in the mouse, Trends Genet, 16, pp. 99-102, (2000)

[2]

Angrand P.-O., Daigle N., Van Der Hoeven F., Schoeler H., Stewart A., Simplified generation of targeting constructs using et recombination, Nucleic Acids Res, 27, (1999)

[3]

Antoch M., Song E.-J., Chang A.-M., Vitaterna M., Zhao Y., Wilsbacher L., Sangoram A., King D., Pinto L., Takahashi J., Functional identification of the mouse circadian Clock gene by transgenic BAC rescue, Cell, 89, pp. 655-667, (1997)

[4]

Beck J., Lloyd S., Hafenparast M., Lennon-Pierce M., Eppig J., Festing M., Fisher E., Genealogies of mouse inbred strains, Nat Genet, 24, pp. 23-25, (2000)

[5]

Bjorheim J., Lystad S., Lindblom A., Kressner U., Westring S., Wahlberg S., Lindmark G., Gaudernack G., Ekstrom G., Roe J.P., Thilly W., Borresen-Dale A., Mutation analyses of KRAS exon 1 comparing three different techniques: Temporal temperature gradient electrophoresis, constant denaturant capillary electrophoresis and allele specific polymerase chain reaction, Mutat Res, 403, pp. 103-112, (1998)

[6]

Bouchard L., Lamarre L., Tremblay P., Jolicoeur P., Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene, Cell, 57, pp. 931-936, (1989)

[7]

Callahan R., Smith G., MMTV-induced mammary tumorigenesis: Gene discovery, progression to malignancy and cellular pathways, Oncogene, 19, pp. 992-1001, (2000)

[8]

Chen Y., Schimenti J., Magnuson T., Toward the yeastification of mouse genetics: Chemical mutagenesis of embryonic stem cells, Mamm Genome, 11, pp. 598-602, (2000)

[9]

Chen Y., Yee D., Dains K., Chatterjee A., Cavalcoli J., Schneider E., Om J., Woychik R., Magnuson T., Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells, Nat Genet, 24, pp. 314-317, (2000)

[10]

Copeland N., Jenkins N., Gilbert D., Eppig J., Maltais L., Miller J., Dietrich W., Weaver A., Lincoln S., Steen R., Stein L., Nadeau J., Lander E., A genetic linkage map of the mouse: Current applications and future prospects, Science, 262, pp. 57-66, (1993)

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