Animal models of the spondyloarthropathies.

被引：6

作者：

Breban M. ^{[1
]}

Falgarone G. ^{[1
]}

Blanchard H. ^{[1
]}

Dernis-Labous E. ^{[1
]}

Lamarque D. ^{[1
]}

机构：

[1] INSERM U477 and Service de Rhumatologie B, Hôpital Cochin, AP-HP, Université René Descartes, 27 rue du Faubourg Saint-Jacques, Paris

来源：

Current Rheumatology Reports | 2000年 / 2卷 / 4期

关键词：

Major Histocompatibility Complex; Human Leukocyte Antigen; Human Leukocyte Antigen Class; Normal Bacterial Flora; Arthritogenic Peptide;

D O I：

10.1007/s11926-000-0064-0

中图分类号：

学科分类号：

摘要：

Several lines of rats transgenic for human leukocyte antigen (HLA)-B27 spontaneously develop a multisystemic inflammatory disease resembling human spondyloarthropathies. This disease is mediated by cells of the immune system and is dependent on the presence of a normal bacterial flora. Both antigen-presenting cells expressing high levels of HLA-B27 and T cells appear to be of importance in the pathogenesis of this model. HLA-B27 transgenic/b2- microglobulin deficient mice also develop arthritis, under the influence of the bacterial flora. In both types of model, CD8+ T cells appear to be unnecessary, arguing against the "arthritogenic peptide" hypothesis.

引用

页码：282 / 287

页数：5

共 104 条

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