Penicillium species as a rare isolate in tracheal granulation tissue: A case series

被引：3

作者：

Randhawa P.S. ^{[1
,2
]}

Nouraei S.A.R. ^{[1
]}

Howard D.J. ^{[2
]}

Sandhu G.S. ^{[1
,2
]}

Petrou M.A. ^{[3
]}

机构：

[1] Department of Otolaryngology, Charing Cross Hospital, London

[2] Royal National Throat Nose and Ear Hospital, London

[3] Department of Medical Mycology, Hammersmith Hospital, London

来源：

Journal of Medical Case Reports | / 2卷 / 1期

关键词：

Itraconazole; Voriconazole; Granulation Tissue; Caspofungin; Minimum Inhibitory Concentration;

D O I：

10.1186/1752-1947-2-84

中图分类号：

学科分类号：

摘要：

Introduction: Granulation tissue formation is a major problem complicating the treatment of upper airway stenosis. We present two cases of recurrent tracheal granulation tissue colonisation by Penicillium species in patients undergoing laryngotracheal reconstructive surgery for post-intubation tracheal stenosis. We believe that although most Penicillium species do not cause invasive disease they can be a contributory factor to the occurrence of upper airway stenosis. Case presentation: A microbiological and mycological study of tracheal granulation tissue in two patients with recurrent laryngotracheal stenosis was carried out. Penicillium species was seen microscopically and cultured from tracheal granulation tissue. Neither patient grew any bacteria known to be associated with airway granulation tissue formation. Amphotericin B, itraconazole, flucytosine voriconazole and caspofungin were highly active against both isolates. Conclusion: A search for a fungal cause should form part of the investigation for recurrent tracheal granulation tissue during laryngotracheal reconstruction. © 2008 Randhawa et al; licensee BioMed Central Ltd.

引用

共 13 条

[1]

Schmal F., Fegeler W., Terpe H.J., Hermann W., Stoll W., Becker K., Bacteria and granulation tissue associated with Montgomery T-tubes, Laryngoscope, 113, pp. 1394-1400, (2003)

[2]

Simoni P., Wiatrak B.J., Microbiology of stents in laryngotracheal reconstruction, Laryngoscope, 114, pp. 364-366, (2004)

[3]

Noppen M., Pierard D., Meysman M., Claes I., Vincken W., Bacterial colonization of central airways after stenting, Am J Respir Crit Care Med, 160, pp. 672-677, (1999)

[4]

Sasaki C.T., Horiuchi M., Koss N., Tracheostomy-related subglottic stenosis: Bacteriologic pathogenesis, Laryngoscope, 89, pp. 857-865, (1979)

[5]

Nouraei S.A., Petrou M.A., Randhawa P.S., Singh A., Howard D.J., Sandhu G.S., Bacterial colonization of airway stents: A promoter of granulation tissue formation following laryngotracheal reconstruction, Arch Otolaryngol Head Neck Surg, 132, pp. 1086-1090, (2006)

[6]

Petrou M.A., Shanson D.C., Susceptibility of Cryptococcus neoformans by the NCCLS microdilution and Etest methods using five defined media, J Antimicrob Chemother, 46, pp. 815-818, (2000)

[7]

Noppen M., Pierard D., Meysman M., Herreweghe R.V., Vincken W., Absence of bacterial colonization of the airways after therapeutic rigid bronchoscopy without stenting, Eur Respir J, 16, pp. 1147-1151, (2000)

[8]

Matt B.H., Myer C.M., Harrison C.J., Reising S.F., Cotton R.T., Tracheal granulation tissue. A study of bacteriology, Arch Otolaryngol Head Neck Surg, 117, pp. 538-541, (1991)

[9]

Noritomi D.T., Bub G.L., Beer I., da Silva A.S., de Cleva R., Gama-Rodrigues J.J., Multiple brain abscesses due to Penicillium spp infection, Rev Inst Med Trop Sao Paulo, 47, pp. 167-170, (2005)

[10]

Hoffman M., Bash E., Berger S.A., Burke M., Yust I., Fatal necrotizing esophagitis due to Penicillium chrysogenum in a patient with acquired immunodeficiency syndrome, Eur J Clin Microbiol Infect Dis, 11, pp. 1158-1160, (1992)

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