Evaluation of bone mineral density of the lumbar spine using a novel phantomless dual-energy CT post-processing algorithm in comparison with dual-energy X-ray absorptiometry

被引：24

作者：

Booz C. ^{[1
]}

Hofmann P.C. ^{[2
]}

Sedlmair M. ^{[2
]}

Flohr T.G. ^{[2
]}

Schmidt B. ^{[2
]}

D’Angelo T. ^{[1
,3
]}

Martin S.S. ^{[1
]}

Lenga L. ^{[1
]}

Leithner D. ^{[1
]}

Vogl T.J. ^{[1
]}

Wichmann J.L. ^{[1
]}

机构：

[1] Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, Frankfurt

[2] Siemens Healthcare, Computed Tomography Division, Forchheim

[3] Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina

来源：

European Radiology Experimental | / 1卷 / 1期

关键词：

Bone mineral density; Computed tomography; Dual-energy computed tomography; Dual-energy X-ray absorptiometry; Osteoporosis;

D O I：

10.1186/s41747-017-0017-2

中图分类号：

学科分类号：

摘要：

Background: Current techniques for evaluation of bone mineral density (BMD) commonly require phantom calibration. The purpose of this study was to evaluate a novel algorithm for phantomless in vivo dual-energy computed tomography (DECT)-based assessment of BMD of the lumbar spine in comparison with dual-energy X-ray absorptiometry (DEXA). Methods: Data from clinically indicated DECT and DEXA examinations within two months comprising the lumbar spine of 47 patients were retrospectively evaluated. By using a novel automated dedicated post-processing algorithm for DECT, the trabecular bone of lumbar vertebrae L1–L4 was selected and analysed. Linear correlation was analysed using Pearson’s product-moment correlation coefficient for the comparison of the results from DECT and DEXA. Results: A total of 186 lumbar vertebrae in 47 patients (mean age, 58 years; age range, 24–85 years) were analysed, 24 men (mean age, 55 years; age range, 24–85 years) and 23 women (mean age, 59 years; age range, 31–80 years). Mean BMD of L1–L4 determined with DEXA was 0.985 g/cm2 and 20/47 patients (42.6%) showed an osteoporotic BMD (T score lower than – 2.5) of at least two vertebrae. Average DECT-based BMD of L1–L4 was 86.8 mg/cm3. Regression analysis demonstrated a lack of correlation between DECT- and DEXA-based BMD values with a Pearson’s product-moment correlation coefficient r = 0.4205. Conclusions: Dedicated post-processing of DECT data using a novel algorithm for retrospective phantomless BMD assessment of the trabecular bone of lumbar vertebrae from clinically indicated DECT examinations is feasible. © 2017, The Author(s).

引用

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