Gene induction during differentiation of human monocytes into dendritic cells: An integrated study at the RNA and protein levels

被引：22

作者：

Angénieux C. ^{[1
]}

Fricker D. ^{[1
]}

Strub J.-M. ^{[2
]}

Luche S. ^{[3
]}

Bausinger H. ^{[1
]}

Cazenave J.-P. ^{[1
]}

Dorsselaer A. ^{[2
]}

Hanau D. ^{[1
]}

De La Salle H. ^{[1
]}

Rabilloud T. ^{[3
]}

机构：

[1] EPI INSERM 9908, Biologie des Cellules Dendritiques, EFS Alsace, 67065 Strasbourg

[2] UMR CNRS 7509, Laboratoire de Spectrométrie de Masse Bio-Organique, ECPM, 67087 Strasbourg

[3] CEA, Laboratoire de BioEnergétique Cellulaire et Pathologique, CEA-Grenoble, 38054 Grenoble, 17, rue des martyrs

来源：

Functional & Integrative Genomics | 2001年 / 1卷 / 5期

关键词：

Dendritic cells; Differentiation; Proteomics; Transcriptomics;

D O I：

10.1007/s101420100037

中图分类号：

学科分类号：

摘要：

Changes in gene expression occurring during differentiation of human monocytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions. These functions encompass antigen processing and presentation, cytoskeleton, cell signalling and signal transduction, but also an increase in mitochondrial function and in the protein synthesis machinery, including some, but not all, chaperones. These changes put in perspective the events occurring during this differentiation process. On a more technical point, it appears that the studies carried out at the RNA and protein levels are highly complementary.

引用

页码：323 / 329

页数：6

共 26 条

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