Relevance of GERD in lung transplant patients

被引：13

作者：

Mertens V. ^{[1
]}

Dupont L. ^{[2
,3
]}

Sifrim D. ^{[4
,5
]}

机构：

[1] Center for Gastroenterological Research, KU Leuven,Leuven

[2] Lung Transplantation Unit, University Hospital Gasthuisberg, KU Leuven,Leuven

[3] Laboratory of Pneumology, KU Leuven,Leuven

[4] Barts and The London School of Medicine and Dentistry, Wingate Institute of Neurogastroenterology, London E12AJ

[5] Catholic University of Leuven, Leuven

来源：

Current Gastroenterology Reports | 2010年 / 12卷 / 3期

关键词：

Bronchial aspiration; Bronchiolitis obliterans syndrome; Gastroesophageal reflux; Lung transplantation;

D O I：

10.1007/s11894-010-0106-3

中图分类号：

学科分类号：

摘要：

Lung transplantation has become a valuable treatment for end-stage pulmonary disorders in an attempt to improve quality of life and extend survival. Development of chronic rejection, also known as bronchiolitis obliterans syndrome (BOS), is responsible for the vast majority of deaths after lung transplantation. Up to 50% of lung transplant patients develop BOS within the first 5 years after transplantation. A high prevalence of gastroesophageal reflux and aspiration of gastric components has been described after lung transplantation. Reflux and aspiration have been implicated in the development of BOS and antireflux surgery has been proposed; however, the causal relationship with BOS and the impact of reflux in lung transplantation survival needs to be further elucidated. © Springer Science+Business Media, LLC 2010.

引用

页码：160 / 166

页数：6

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