Ischemic preconditioning of the rat brain as a method of endothelial protection from ischemic/repercussion injury

被引：49

作者：

Vlasov T.D. ^{[1
]}

Korzhevskii D.É. ^{[2
]}

Polyakova E.A. ^{[1
]}

机构：

[1] Academician Pavlov St. Petersburg State Medical University, 197022 St. Petersburg

[2] Institute of Experimental Medicine, Russian Academy of Medical Sciences, 197022 St. Petersburg

来源：

Neuroscience and Behavioral Physiology | 2005年 / 35卷 / 6期

关键词：

Brain; Endothelium; Ischemia; Ischemic preconditioning; Nitric oxide; Reperfusion;

D O I：

10.1007/s11055-005-0095-0

中图分类号：

学科分类号：

摘要：

The studies reported here addressed the endothelium-protecting action of local and remote ischemic preconditioning of the brain in rats. Cerebral ischemia lasting 30 min was reproduced by thermocoagulation of the vertebral arteries with simultaneous clamping of the carotid arteries, the procedure being followed by reperfusion via the carotid arteries for 120 min (controls). The early and late phases of ischemic preconditioning and remote preconditioning were reproduced. Brain blood flow was recorded using high-frequency Doppler ultrasonography. The early and late phases of local ischemic preconditioning and the late phase of remote ischemic preconditioning were found to have endothelium-protecting actions apparent as improvements in the recovery of brain blood flow in the post-ischemic period in preconditioned rats, with lower levels of endothelial desquamation and cerebral edema. Blockade of nitric oxide synthesis eliminated the protective effects of both phases of preconditioning. © 2005 Springer Science+Business Media, Inc.

引用

页码：567 / 572

页数：5

共 22 条

[1]

Viktorov I.V., The role of nitric oxide and other free radicals in ischemic pathology of the brain, Izv. Ross. Akad. Med. Nauk., 4, pp. 5-10, (2000)

[2]

Vlasov T.D., The reactivity of vessels and the parameters of thrombus formation in post-ischemic reperfusion, Ros. Fiziol. Zh. Im. I. M. Sechenova, 85, 11, pp. 1391-1395, (1999)

[3]

Vlasov T.D., Smirnov D.A., Nutfullina G.M., Adaptation of the small intestine of rats to ischemia, Ros. Fiziol. Zh. Im. I. M. Sechenova, 87, 1, pp. 118-124, (2001)

[4]

Gurin A.V., Molosh A.I., Sidorenko G.I., Interrupted ischemia - A unique adaptive phenomenon. Perspective of new pathways of pharmacological action, Kardiologiya, 6, pp. 45-52, (1997)

[5]

Kozlov V.A., Artyushenko N.K., Shalak O.V., Vasil'ev A.V., Girina M.B., Girin I.I., Morozova E.A., Monastyrenko A.A., Doppler Ultrasonography in Assessing the Hemodynamics of Tissues in the Neck, Face, and Oral Cavity in Normal Conditions and Various Pathological States. A Handbook-Atlas, (2000)

[6]

Petrishchev N.N., Shlyakhto E.V., Vlasov T.D., Galagudza M.M., The phenomenon of ischemic adaptation of the myocardium - Pathophysiological mechanisms and possible perspectives of practical application, Ros. Fiziol. Zh. Im. I. M. Sechenova, 87, 5, pp. 688-705, (2001)

[7]

Petrishchev N.N., Vlasov T.D., The functional state of the endothelium in ischemia/reperfusion (literature review), Ros. Fiziol. Zh. Im. I. M. Sechenova, 86, 2, pp. 148-163, (2000)

[8]

Petrishchev N.N., Berkovich O.A., Vlasov T.D., Volkova E.V., Zueva E.B., Mozgovaya E.B., The diagnostic value of measurements of desquamated endothelial cells in blood, Klin. Lab. Diagnostika, 1, pp. 50-52, (2001)

[9]

Semenyutin V.B., Zubkov Yu.N., Lomova I.P., Circulation, oxidative metabolism, and intravascular kinin formation in the brain in ischemia and reperfusion, Proceedings of the IV International 'Brain Ischemia' Symposium, pp. 153-158, (1997)

[10]

Castillo J., Rama R., Davalos A., Nitric oxide-related brain damage in acute ischemic stroke, Stroke, 31, 4, pp. 852-857, (2000)

← 1 2 3 →