Methotrexate versus hyperosomolar glucose in the treatment of extrauterine pregnancy

被引：11

作者：

Sadan O. ^{[1
]}

Ginath S. ^{[1
]}

Debby A. ^{[1
]}

Rotmensch S. ^{[1
]}

Golan A. ^{[1
]}

Zakut H. ^{[1
]}

Glezerman M. ^{[1
]}

机构：

[1] Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University

来源：

Archives of Gynecology and Obstetrics | 2001年 / 265卷 / 2期

关键词：

Ectopic pregnancy; Hyperosmolar glucose; Methotrexate;

D O I：

10.1007/s004040000149

中图分类号：

学科分类号：

摘要：

The aim of this prospective, randomized, double-blind study was to compare the efficacy of methotrexate and hyperosmolar glucose injected directly into the extra-uterine gestational sac under laparoscopic vision. The study included twenty women with ectopic pregnancy. Inclusion criteria were intact tubal pregnancy, not exceeding 4 cm in diameter, rising or plateauing βhCG levels, and no evidence of intra-abdominal bleeding. The patients were treated by laparoscopically guided injection of 3 mL fluid into the area containing the tubal pregnancy. The fluid contained either 25 mg methotrexate (n=9) or 50% glucose (n=9). Daily decrease in βhCG levels was faster in patients treated by methotrexate (median 8.7%) than in those treated by hyperosmolar glucose (median 4.8%), p=0.17. The study was discontinued due to a higher failure rate in the group treated by hyperosmolar glucose. In conclusion, local injection of methotrexate is superior to hyperosmolar glucose. It can be used as an alternative to salpingostomy or salpingotomy whenever laparoscopy is performed for the diagnosis and treatment of extra-uterine pregnancy.

引用

页码：82 / 84

页数：2

共 11 条

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