Management of infections caused by Candida glabrata

被引：11

作者：

Jack D. Sobel

机构：

[1] Wayne State University School of Medicine and Harper Hospital,Department of Internal Medicine

来源：

Current Infectious Disease Reports | 2000年 / 2卷 / 5期

关键词：

Fluconazole; Candidiasis; Azole; Candida Species; Antimicrob Agent;

D O I：

10.1007/s11908-000-0069-x

中图分类号：

学科分类号：

摘要：

Candida glabrata infections undoubtedly have become more frequent, and are now common. They appear to be the consequence of widespread and often indiscriminate use of azoles, especially fluconazole. This species constitutes the Achilles heel of all available azoles, including newer ones in the pipeline. Even when amphotericin B is used, higher dosages are now required. Little is known about the epidemiology of and risk factors for this troublesome species; even less about its virulence factors. However, studying the resistance mechanisms of this haploid organism may provide answers in developing new fungicidal agents.

引用

页码：424 / 428

页数：4

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