The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: A case report

被引：37

作者：

Skibola C.F. ^{[1
]}

机构：

[1] School of Public Health, Molec. Epidemiology/Toxicology Lab., University of California, Berkeley

来源：

BMC Complementary and Alternative Medicine | / 4卷 / 1期

关键词：

Breast Cancer Risk; Menstrual Cycle; Endometriosis; Progesterone Level; Fucus Vesiculosus;

D O I：

10.1186/1472-6882-4-10

中图分类号：

学科分类号：

摘要：

Background: Rates of estrogen-dependent cancers are among the highest in Western countries and lower in the East. These variations may be attributable to differences in dietary exposures such as higher seaweed consumption among Asian populations. The edible brown kelp, Fucus vesiculosus (bladderwrack), as well as other brown kelp species, lower plasma cholesterol levels. Since cholesterol is a precursor to sex hormone biosynthesis, kelp consumption may alter circulating sex hormone levels and menstrual cycling patterns. In particular, dietary kelp may be beneficial to women with or at high risk for estrogen-dependent diseases. To test this, bladderwrack was administered to three pre-menopausal women with abnormal menstrual cycling patterns and/or menstrual-related disease histories. Case Presentation: Intake of bladderwrack was associated with significant increases in menstrual cycle lengths, ranging from an increase of 5.5 to 14 days. In addition, hormone measurements ascertained for one woman revealed significant anti-estrogenic and progestagenic effects following kelp administration. Mean baseline 17β-estradiol levels were reduced from 626 ± 91 to 164 ± 30 pg/ml (P = 0.04) following 700 mg/d, which decreased further to 92.5.0 ± 3.5pg/ml (P = 0.03) with the 1.4 g/d dose. Mean baseline progesterone levels rose from 0.58 ± 0.14 to 8.4 ± 2.6 ng/ml with the 700 mg/d dose (P = 0.1), which increased further to 16.8 ± 0.7 ng/ml with the 1.4 g/d dose (P = 0.002). Conclusions: These pilot data suggest that dietary bladderwrack may prolong the length of the menstrual cycle and exert anti-estrogenic effects in pre-menopausal women. Further, these studies also suggest that seaweed may be another important dietary component apart from soy that is responsible for the reduced risk of estrogen-related cancers observed in Japanese populations. However, these studies will need to be performed in well-controlled clinical trials to confirm these preliminary findings. © 2004 Skibola; licensee BioMed Central Ltd.

引用

页数：8

共 46 条

[1]

Parkin D.M., Pisani P., Ferlay J., Estimates of the worldwide incidence of 25 major cancers in 1990, Int. J. Cancer, 80, pp. 827-841, (1999)

[2]

Parkin D.M., Pisani P., Ferlay J., Global cancer statistics, CA Cancer J. Clin., 49, pp. 33-64, (1999)

[3]

Madigan M.P., Troisi R., Potischman N., Dorgan J.F., Brinton L.A., Hoover R.N., Serum hormone levels in relation to reproductive and lifestyle factors in postmenopausal women, Cancer Causes Control, 9, pp. 199-207, (1998)

[4]

McTiernan A., Behavioral risk factors in breast cancer: Can risk be modified?, Oncologist, 8, pp. 326-334, (2003)

[5]

Tavani A., Bosetti C., Dal Maso L., Giordano L., Franceschi S., La Vecchia C., Influence of selected hormonal and lifestyle factors on familial propensity to ovarian cancer, Gynecol. Oncol., 92, pp. 922-926, (2004)

[6]

Cauley J.A., Lucas F.L., Kuller L.H., Stone K., Browner W., Cummings S.R., Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Research Group, Ann. Intern. Med., 130, pp. 270-277, (1999)

[7]

Hankinson S.E., Willett W.C., Manson J.E., Colditz G.A., Hunter D.J., Spiegelman D., Barbieri R.L., Speizer F.E., Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women, J. Natl. Cancer Inst., 90, pp. 1292-1299, (1998)

[8]

Baskin G.B., Smith S.M., Marx P.A., Endometrial hyperplasia, polyps, and adenomyosis associated with unopposed estrogen in rhesus monkeys (Macaca mulatta), Vet. Pathol., 39, pp. 572-575, (2002)

[9]

Yue W., Santen R.J., Wang J.P., Li Y., Verderame M.F., Bocchinfuso W.P., Korach K.S., Devanesan P., Todorovic R., Rogan E.G., Cavalieri E.L., Genotoxic metabolites of estradiol in breast: Potential mechanism of estradiol induced carcinogenesis, J. Steroid. Biochem. Mol. Biol., 86, pp. 477-486, (2003)

[10]

Hinkula M., Pukkala E., Kyyronen P., Kauppila A., Grand multiparity and incidence of endometrial cancer: A population-based study in Finland, Int. J. Cancer, 98, pp. 912-915, (2002)

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