Chronic cough, asthma, and gastroesophageal reflux.

被引：15

作者：

Lazenby J.P. ^{[1
]}

Harding S.M. ^{[1
]}

机构：

[1] Division of Pulmonary, Allergy, and Critical Care Medicine

来源：

Current Gastroenterology Reports | 2000年 / 2卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Asthma; Omeprazole; Gastroesophageal Reflux; Chronic Cough; Neurogenic Inflammation;

D O I：

10.1007/s11894-000-0064-2

中图分类号：

学科分类号：

摘要：

Gastroesophageal reflux disease (GERD) causes chronic cough and triggers asthma. Mechanisms of reflux-associated chronic cough include micro- and macroaspiration, laryngeal injury, and a vagally mediated reflex. An empiric trial of a proton pump inhibitor in patients without other etiologies of cough found through diagnostic testing may be an effective diagnostic strategy for GERD-associated cough. In GERD-associated asthma, there is evidence of neurogenic inflammation. Medical or surgical therapy of GERD results in asthma symptom improvement in about 70% of patients. A 3-month empiric trial of omeprazole, 20 mg daily, followed by esophageal pH testing in drug nonresponders, is the most cost-effective way of diagnosing asthma triggered by GERD.

引用

页码：217 / 223

页数：6

共 90 条

[1]

Locke GR(1997)Prevalence and clinical spectrum of gastroesophageal reflux: a population based study in Olmsted County, Minnesota Gastroenterology 112 1448-1356

[2]

Talley NJ(1981)Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy Am Rev Respir Dis 123 413-417

[3]

Fett SL(1999)A pathogenic trial in chronic cough: asthma, postnasal drip syndrome and gastroesophageal reflux disease Chest 116 279-284

[4]

Irwin RS(1997)Proceedings of First Multi-Disciplinary International Symposium On Supraesophageal Complications of Reflux Disease Am J Med 103 91S-96S

[5]

Corrao WM(1999)Ineffective esophageal motility: the most common motility abnormality in patients with GERD-associated respiratory symptoms Am J Gastroenterol 94 1464-1467

[6]

Pratter MR(1998)Extrathoracic airway dysfunction in cough associated with gastroesophageal reflux J Allergy Clin Immunol 102 204-209

[7]

Palombini BC(1994)Pathogenesis of chronic persistent cough associated with gastroesophageal reflux Am J Respir Crit Care Med 149 160-167

[8]

Villanova CAC(1998)Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol Thorax 53 738-743

[9]

Araujo E(1989)Chronic cough as the sole presenting manifestation of gastroesophageal reflux Am Rev Respir Dis 140 1294-1300

[10]

Ing AJ(1999)Twenty-four hour ambulatory esophageal pH monitoring in the diagnosis of acid reflux-related chronic cough South Med J 90 305-311

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