The role of G proteins in the psychobiology and treatment of affective disorders and their integration with the neurotransmitter hypothesis.

被引：10

作者：

Avissar S. ^{[1
]}

机构：

[1] Department of Clinical Pharmacology, Ben Gurion University of the Negev, PO Box 653

来源：

Current Psychiatry Reports | 1999年 / 1卷 / 2期

关键词：

Bipolar Disorder; Mood Disorder; Biol Psychiatry; Bipolar Affective Disorder; Mononuclear Leukocyte;

D O I：

10.1007/s11920-999-0024-y

中图分类号：

学科分类号：

摘要：

Heterotrimeric G proteins are a crucial point of convergence in the transmission of signals from a variety of primary messengers and their membrane receptors to downstream intracellular second messenger effector enzymes and ionic channels. Thus, these proteins have raised increasing interest in the clinical perspective of altered G protein function. This article addresses the most recent significant findings regarding the role of G proteins in the pathophysiology of mood disorders and in the molecular mechanisms underlying the treatment of these disorders, with emphasis on biochemical and genetic approaches.

引用

页码：148 / 153

页数：5

共 137 条

[1]

Gilman AG(1987)G proteins. Transducers of receptor-generated signals Annu Rev Biochem 56 615-649

[2]

Avissar S(1988)Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex Nature 331 440-442

[3]

Schreiber G(1989)Muscarinic receptor subclassification and G proteins: Significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics. (Bennett Award Paper Biol Psychiatry 26 113-130

[4]

Danon A(1990)Lithium-selective alteration of brain vs. cardiac Gs protein function Neuropharmacology 29 1067-1071

[5]

Avissar S(1992)The involvement of G proteins in the pathogenesis and treatment of affective disorders. (Ziskind-Somerfeld Award Paper) Biol Psychiatry 31 435-459

[6]

Schreiber G(1992)Interaction of antibipolar and antidepressant treatments with receptor-coupled G proteins. (Anna Monika Award Paper Pharmacopsychiatry 25 44-50

[7]

Schreiber G(1991)Magnesium reverses lithium inhibition of beta adrenergic and muscarinic receptor coupling to G proteins Biochem Pharmacol 41 171-175

[8]

Avissar S(1989)Electrophysiological demonstration of transducin inhibition by lithium C R Acad Sci Paris 309 289-294

[9]

Avissar S(1989)Effects of GTP on hormone-stimulated adenylate cyclase activity in cerebral cortex, striatum and hippocampus from rats treated chronically with lithium Biol Psychiatry 26 279-288

[10]

Schreiber G(1991)Effects of lithium and desipramine on second messenger responses in rat hippocampus: relation to G protein effects Neuropharmacology 30 1297-13101

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