Diet and C-reactive protein

被引：31

作者：

Peter M. Clifton

机构：

[1] CSIRO Health Sciences and Nutrition, Adelaide, SA 5000

来源：

Current Atherosclerosis Reports | 2003年 / 5卷 / 6期

关键词：

Metabolic Syndrome; Conjugate Linoleic Acid; Lycopene; Arterioscler Thromb Vasc Biol; Glycemic Load;

D O I：

10.1007/s11883-003-0032-z

中图分类号：

学科分类号：

摘要：

C-reactive protein (CRP) is an independent predictor of cardiovascular events in healthy individuals and those with pre-existing disease. It also probably contributes to the disease process. CRP levels are higher in obese subjects and this link is almost certainly because of increased insulin resistance. Interventions that alter insulin resistance, such as weight loss, exercise, and conjugated linoleic acid, also alter CRP. Glycemic load is associated with CRP, but there have been no interventions with altered macronutrient composition. In the context of weight loss, macronutrient composition is probably not important. Alcohol lowers CRP, but the mechanism is unknown. The interaction between gender and obesity needs further work, but it appears that obesity has a greater effect on CRP levels in wowen. Copyright © 2003 by Current Science Inc.

引用

页码：431 / 436

页数：5

共 51 条

[1]

Ridker P.M., Clinical application of C-reactive protein for cardiovascular disease detection and prevention, Circulation, 107, pp. 363-369, (2003)

[2]

Heilbronn L.K., Clifton P.M., C-reactive protein and coronary artery disease: Influence of obesity, caloric restriction and weight loss, J. Nutr. Biochem., 13, pp. 316-321, (2002)

[3]

Wang C.H., Li S.H., Weisel R.D., Et al., C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle, Circulation, 107, pp. 1783-1790, (2003)

[4]

Devaraj S., Xu D.Y., Jialal I., C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: Implications for the metabolic syndrome and atherothrombosis, Circulation, 107, pp. 398-404, (2003)

[5]

Verma S., Li S.H., Badiwala M.V., Et al., Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein, Circulation, 105, pp. 1890-1896, (2002)

[6]

Pasceri V., Cheng J.S., Willerson J.T., Et al., Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs, Circulation, 103, pp. 2531-2534, (2001)

[7]

Connelly P.W., Hanley A.J., Harris S.B., Et al., Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree, Int. J. Obes. Relat. Metab. Disord., 27, pp. 347-354, (2003)

[8]

Fernandez-Real J.M., Vayreda M., Richart C., Et al., Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women, J. Clin. Endocrinol. Metab., 86, pp. 1154-1159, (2001)

[9]

de Maat M.P., Kluft C., The association between inflammation markers, coronary artery disease and smoking, Vasc. Pharmacol., 39, pp. 137-139, (2002)

[10]

Heilbronn L.K., Noakes M., Clifton P.M., Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women, Arterioscler. Thromb. Vasc. Biol., 21, pp. 968-970, (2001)

← 1 2 3 4 5 6 →