Testosterone replacement therapy and prostate cancer: A word of caution

被引：20

作者：

Brand T.C. ^{[1
]}

Canby-Hagino E. ^{[1
]}

Thompson I.M. ^{[1
]}

机构：

[1] Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229

来源：

Current Urology Reports | 2007年 / 8卷 / 3期

关键词：

Prostate Cancer; Testosterone; Digital Rectal Examination; Free Testosterone; Prostatic Intraepithelial Neoplasia;

D O I：

10.1007/s11934-007-0004-x

中图分类号：

学科分类号：

摘要：

The number of men for whom testosterone is prescribed is rapidly Increasing. The aging man normally demonstrates a gradual decline in testosterone. Symptoms of hypogonadism include erectile dysfunction, diminished libido, sarcopenia, increased adiposity, osteopenia and osteoporosis, impaired cognition, and depression. There is a paucity of data regarding both efficacy and safety of testosterone replacement therapy. Testosterone levels have been shown to modulate prostate cancer risk and progression. A prospective evaluation of prostate cancer risk with testosterone replacement therapy has not been conducted. We outline concerns and recommendations for the use of testosterone replacement therapy in the aging man. Copyright © 2007 by Current Medicine Croup LLC.

引用

页码：185 / 189

页数：4

共 60 条

[1]

Gore J., Raifer J., Testosterone and the aging male: Where do we stand?, Am J Urol Rev, 3, pp. 440-442, (2005)

[2]

Isidori A.M., Greco E.A., Aversa A., Androgen deficiency and hormone-replacement therapy, BJU Int, 96, pp. 212-216, (2005)

[3]

Haren M.T., Morley J.E., Chapman I.M., Et al., Defining 'relative' androgen deficiency in aging men: How should testosterone be measured and what are the relationships between androgen levels and physical, sexual and emotional health?, Climacteric, 5, pp. 15-25, (2002)

[4]

Katz A., Androgen replacement therapy in aging men, Nurse Tract, 29, pp. 58-64, (2004)

[5]

Blazer D., Testosterone and Aging: Clinical Research Directions, (2003)

[6]

Tenover J.S., Declining testicular function in aging men, Int J Impot Res, 15, SUPPL. 4, (2003)

[7]

Mohr B.A., Guay A.T., O'Donnell A.B., Et al., Normal, bound and nonbound testosterone levels in normally ageing men: Results from the Massachusetts Male Ageing Study, Clin Endocrinol (Oxf), 62, pp. 64-73, (2005)

[8]

J Clin Endocrinol Metab, 86, pp. 4611-4614, (2001)

[9]

Diver M.J., Imtiaz K.E., Ahmad A.M., Et al., Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men, Clin Endocrinol, 58, pp. 710-717, (2003)

[10]

Broderick G.A., Lue T.F., Evaluation and nonsurgical management of erectile dysfunction and priapism, Campbell's Urology, pp. 1619-1671, (2002)

← 1 2 3 4 5 6 →