Quantitative and qualitative differences in subcutaneous adipose tissue stores across lipodystrophy types shown by magnetic resonance imaging

被引：20

作者：

Al-Attar S.A. ^{[1
]}

Pollex R.L. ^{[1
]}

Robinson J.F. ^{[1
]}

Miskie B.A. ^{[1
]}

Walcarius R. ^{[2
]}

Little C.H. ^{[2
]}

Rutt B.K. ^{[2
]}

Hegele R.A. ^{[1
,3
,4
]}

机构：

[1] Vascular Biology Research Group, Robarts Research Institute, London

[2] Imaging Research Laboratories, Robarts Research Institute, London

[3] Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London

[4] Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, ON N6A 5K8

来源：

BMC Medical Imaging | / 7卷 / 1期

关键词：

Visceral Adipose Tissue; Subcutaneous Adipose Tissue; Lipodystrophy; Lipodystrophy Syndrome; Adipose Tissue Distribution;

D O I：

10.1186/1471-2342-7-3

中图分类号：

学科分类号：

摘要：

Background: Lipodystrophies are characterized by redistributed subcutaneous fat stores. We previously quantified subcutaneous fat by magnetic resonance imaging (MRI) in the legs of two patients with familial partial lipodystrophy subtypes 2 and 3 (FPLD2 and FPLD3, respectively). We now extend the MRI analysis across the whole body of patients with different forms of lipodystrophy. Methods: We studied five subcutaneous fat stores (supraclavicular, abdominal, gluteal, thigh and calf) and the abdominal visceral fat stores in 10, 2, 1, 1 and 2 female subjects with, respectively, FPLD2, FPLD3, HIV-related partial lipodystrophy (HIVPL), acquired partial lipodystrophy (APL), congenital generalized lipodystrophy (CGL) and in six normal control subjects. Results: Compared with normal controls, FPLD2 subjects had significantly increased supraclavicular fat, with decreased abdominal, gluteal, thigh and calf subcutaneous fat. FPLD3 subjects had increased supraclavicular and abdominal subcutaneous fat, with less severe reductions in gluteal, thigh and calf fat compared to FPLD2 subjects. The repartitioning of fat in the HIVPL subject closely resembled that of FPLD3 subjects. APL and CGL subjects had reduced upper body, gluteal and thigh subcutaneous fat; the APL subject had increased, while CGL subjects had decreased subcutaneous calf fat. Visceral fat was markedly increased in FPLD2 and APL subjects. Conclusion: Semi-automated MRI-based adipose tissue quantification indicates differences between various lipodystrophy types in these studied clinical cases and is a potentially useful tool for extended quantitative phenomic analysis of genetic metabolic disorders. Further studies with a larger sample size are essential for confirming these preliminary findings. © 2007 Al-Attar et al; licensee BioMed Central Ltd.

引用

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