Randomized clinical stroke trials in 2004

被引：4

作者：

Rabadi M.H. ^{[1
]}

Blass J. ^{[1
]}

机构：

[1] Burke Rehabilitation Hospital and Medical Research Institute, Weill Medical College of Cornell University, White Plains, NY 10605

来源：

Current Atherosclerosis Reports | 2005年 / 7卷 / 4期

关键词：

Simvastatin; Triflusal; QBUJFOUT XJUI; Clinical Stroke Trial; IJHI SJTL;

D O I：

10.1007/s11883-005-0025-1

中图分类号：

学科分类号：

摘要：

Randomized clinical stroke trials published during 2004 dealt primarily with prevention of strokes by reducing risk factors. The usefulness of innovative versions of widely known treatment modalities was documented. These included angiotensin-converting enzyme inhibitors against hypertension, acarabose against diabetes, and the antiplatelet agent triflusal instead of aspirin. A large British study confirmed the value of treatment with simvastatin. Appropriately powered studies found no benefit for stroke prevention of either vitamin treatment to lower homocysteine or hormonal replacement in post-menopausal women. The circumstances under which antithrombotic, anticoagulant and surgical treatments of acute ischemic stroke are appropriate were further specified. Copyright © 2005 by Current Science Inc.

引用

页码：319 / 325

页数：6

共 19 条

[1]

Zanchetti A., Crepaldi G., Bond M.G., Et al., Different effects of antihypertensive regimens based on fosinopril or hydrochlorothiazide with or without lipid lowering by pravastatin on progression of asymptomatic carotid atherosclerosis: Principal results of PHYLLIS - A randomized double-blind trial, Stroke, 35, pp. 2807-2812, (2004)

[2]

Lonn E., Yusuf S., Dzavik V., Et al., Effects of ramipril and vitamin E on atherosclerosis: The study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE), Circulation, 103, pp. 919-925, (2001)

[3]

Hanefeld M., Chiasson J.L., Koehler C., Et al., Acarbose slows progression of intima-media thickness of the carotid arteries in subjects with impaired glucose tolerance, Stroke, 35, pp. 1073-1078, (2004)

[4]

Chiasson J.L., Josse R.G., Gomis R., Et al., Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomized trial, Lancet, 359, pp. 2072-2077, (2002)

[5]

Collins R., Armitage J., Parish S., Et al., Effects of cholesterol lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions, Lancet, 363, pp. 757-767, (2004)

[6]

Anderson G.L., Limacher M., Assaf A.R., Et al., Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial, JAMA, 291, pp. 1701-1712, (2004)

[7]

Culebras A., Rotta-Escalante R., Vila J., Et al., Triflusal vs. aspirin for prevention of cerebral infarction: A randomized stroke study, Neurology, 62, pp. 1073-1080, (2004)

[8]

Matias-Guiu J., Ferro J.M., Alvarez-Sabin J., Et al., Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: The TACIP Study: A randomized, double blind, multicenter trial, Stroke, 34, pp. 840-848, (2003)

[9]

Diener H.C., Bogousslavsky J., Brass L.M., Et al., Aspirin and clopidogrel compared with clopidogrel alone after recent ischemic stroke or transient ischemic attack in high-risk patients (MATCH): Randomized, double blind, placebo-controlled trial, Lancet, 364, pp. 331-337, (2004)

[10]

LaMonte M.P., Nash M.L., Wang D.Z., Et al., Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): A randomized, placebo-controlled safety study, Stroke, 35, pp. 1677-1682, (2004)

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