The Nelson's syndrome... revisited

被引：45

作者：

Assié G. ^{[1
]}

Bahurel H. ^{[2
]}

Bertherat J. ^{[1
]}

Kujas M. ^{[3
]}

Legmann P. ^{[2
]}

Bertagna X. ^{[1
]}

机构：

[1] Université René Descartes, Endocrinology Department, Cochin Hospital, 75014 Paris 5

[2] Radiology Department, Cochin Hospital, 75014 Paris 5

[3] Pathology Department, La Pitié Hospital, Paris

来源：

Pituitary | 2004年 / 7卷 / 4期

关键词：

Public Health; Magnetic Resonance Imaging; Tumor Growth; Tumor Progression; Therapeutic Approach;

D O I：

10.1007/s11102-005-1403-y

中图分类号：

学科分类号：

摘要：

Adrenalectomy is a radical therapeutic approach to control hypercortisolism in some patients with Cushing's disease. However it may be complicated by the Nelson's syndrome, defined by the association of a pituitary macroadenoma and high ACTH secretion after adrenalectomy. This definition has not changed since the end of the fifties. Today the Nelson's syndrome must be revisited with new to criteria using more sensitive diagnostic tools, especially the pituitary magnetic resonance imaging. In this paper we will review the pathophysiological aspects of corticotroph tumor growth, with reference to the impact of adrenalectomy. The main epidemiological data on the Nelson's syndrome will be presented. More importantly, we will propose a new pathophysiological and practical approach to this question which attempts to evaluate the Corticotroph Tumor Progression after adrenalectomy, rather than to diagnose the Nelson's syndrome. We will discuss the consequences for the management of Cushing's disease patients after adrenalectomy, and will also draw some perspectives. © Springer Science + Business Media, Inc. 2005.

引用

页码：209 / 215

页数：6

共 69 条

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