Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: A case control study

被引：31

作者：

Annells M.F. ^{[1
,2
]}

Hart P.H. ^{[2
]}

Mullighan C.G. ^{[3
]}

Heatley S.L. ^{[3
]}

Robinson J.S. ^{[4
]}

McDonald H.M. ^{[1
]}

机构：

[1] Department of Microbiology and Infectious Diseases, Women's and Children's Hospital, North Adelaide, SA 5006

[2] Department of Microbiology and Infectious Diseases, Flinders University, Bedford Park

[3] Australian Red Cross Blood Services, Adelaide, SA 5000

[4] Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide

来源：

BMC Pregnancy and Childbirth | / 5卷 / 1期

关键词：

Adverse Pregnancy Outcome; Chorioamnionitis; Vulvovaginal Candidiasis; Placenta Praevia; MBL2 Gene;

D O I：

10.1186/1471-2393-5-4

中图分类号：

学科分类号：

摘要：

Background: Chorioamnionitis is a common underlying cause of preterm birth (PTB). It is hypothesised that polymorphisms in immunoregulatory genes influence the host response to infection and subsequent preterm birth. The relationship between histologic chorioamnionitis and 22 single nucleotide polymorphisms in 11 immunoregulatory genes was examined in a case-control study. Methods: Placentas of 181 Caucasoid women with spontaneous PTB prior to 35 weeks were examined for histologic chorioamnionitis. Polymorphisms in genes IL1A, IL1B, IL1RN, IL1R1, tumour necrosis factor (TNF), IL4, IL6, IL10, transforming growth factor beta-1 (TGFB1), Fas (TNFRSF6), and mannose-binding lectin (MBL2) were genotyped by polymerase chain reaction and sequence specific primers. Multivariable logistic regression including demographic and genetic variables and Kaplan-Meier survival analyses of genotype frequencies and pregnancy outcome were performed. Results: Sixty-nine (34%) women had histologic evidence of acute chorioamnionitis. Carriage of the IL10-1082A/-819T/592A (ATA) haplotype [Multivariable Odds ratio (MOR) 1.9, P = 0.05] and MBL2 codon 54Asp allele (MOR 2.0, P = 0.04), were positively associated with chorioamnionitis, while the TNFRSF6-1377A/-670G (AG) haplotype (MOR 0.4, P = 0.03) and homozygosity for TGFB1-800G/509T (GT) haplotype (MOR 0.2, P = 0.04) were negatively associated. Conclusion: These findings demonstrate that polymorphisms in immunoregulatory genes IL10, MBL2, TNFRSF6 and TGFB1 may influence susceptibility to chorioamnionitis. © 2005 Annells et al; licensee BioMed Central Ltd.

引用

页数：9

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