Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings

被引：42

作者：

Allen J.L. ^{[1
]}

Klocke C. ^{[1
]}

Morris-Schaffer K. ^{[1
]}

Conrad K. ^{[1
]}

Sobolewski M. ^{[1
]}

Cory-Slechta D.A. ^{[2
]}

机构：

[1] Department of Environmental Medicine, University of Rochester Medical Center, Rochester, 14642, NY

[2] Box EHSC, University of Rochester Medical Center, Rochester, 14642, NY

来源：

Current Environmental Health Reports | 2017年 / 4卷 / 2期

关键词：

Air pollution; Attention; Glutamate; Inflammation; Learning; Memory;

D O I：

10.1007/s40572-017-0134-3

中图分类号：

学科分类号：

摘要：

Purpose of Review: This review sought to address the potential for air pollutants to impair cognition and mechanisms by which that might occur. Recent Findings: Air pollution has been associated with deficits in cognitive functions across a wide range of epidemiological studies, both with developmental and adult exposures. Studies in animal models are significantly more limited in number, with somewhat inconsistent findings to date for measures of learning, but show more consistent impairments for short-term memory. Potential contributory mechanisms include oxidative stress/inflammation, altered levels of dopamine and/or glutamate, and changes in synaptic plasticity/structure. Summary: Epidemiological studies are consistent with adverse effects of air pollutants on cognition, but additional studies and better phenotypic characterization are needed for animal models, including more precise delineation of specific components of cognition that are affected, as well as definitions of critical exposure periods for such effects and the components of air pollution responsible. This would permit development of more circumscribed hypotheses as to potential behavioral and neurobiological mechanisms. © 2017, Springer International Publishing AG.

引用

页码：180 / 191

页数：11

共 99 条

[1]

Forouzanfar M.H., Alexander L., Anderson H.R., Bachman V.F., Biryukov S., Brauer M., Et al., Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013, Lancet, pp. 2287-2323, (2015)

[2]

Lelieveld J., Evans J.S., Fnais M., Giannadaki D., Pozzer A., The contribution of outdoor air pollution sources to premature mortality on a global scale, Nature, 525, 7569, pp. 367-371, (2015)

[3]

Kumar P., Morawska L., Birmili W., Paasonen P., Hu M., Kulmala M., Et al., Ultrafine particles in cities, Environ Int, 66, pp. 1-10, (2014)

[4]

Oberdorster G., Ferin J., Lehnert B.E., Correlation between particle size, in vivo particle persistence, and lung injury, Environ Health Perspect, 102, pp. 173-179, (1994)

[5]

Brown D.M., Wilson M.R., MacNee W., Stone V., Donaldson K., Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines, Toxicol Appl Pharmacol, 175, 3, pp. 191-199, (2001)

[6]

Elder A., Gelein R., Silva V., Feikert T., Opanashuk L., Carter J., Et al., Translocation of inhaled ultrafine manganese oxide particles to the central nervous system, Environ Health Perspect, 114, 8, pp. 1172-1178, (2006)

[7]

Lewis J., Bench G., Myers O., Tinner B., Staines W., Barr E., Et al., Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice, Neurotoxicology, 26, 1, pp. 113-123, (2005)

[8]

Ruuskanen J., Tuch T., Brink T., Peters A., Khlystov A., Mirme A., Et al., Concentrations of ultrafine, fine and PM2.5 particles in three European cities, Atmos Environ, 35, pp. 3728-3729, (2001)

[9]

Pitz M., Kreyling W.G., Holscher B., Cyrys J., Wichmann H.E., Heinrich J., Change of the ambient particle size distribution in East Germany between 1993 and 1999, Atmos Environ, 35, 25, pp. 4357-4366, (2001)

[10]

Martins L.D., Martins J.A., Freitas E.D., Mazzoli C.R., Goncalves F.L.T., Ynoue R.Y., Et al., Potential health impact of ultrafine particles under clean and polluted urban atmospheric conditions: a model-based study, Air Quality Atmosphere and Health, 3, 1, pp. 29-39, (2010)

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