Reciprocal inhibition of the AMPA and NMDA components of excitatory postsynaptic potentials in field CA1 of the rat hippocampus in vitro

被引：5

作者：

Bazhenov A.V. ^{[1
]}

Kleshchevnikov A.M. ^{[1
]}

机构：

[1] Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow

来源：

Neuroscience and Behavioral Physiology | 1999年 / 29卷 / 6期

基金：

俄罗斯基础研究基金会;

关键词：

NMDA Receptor; AMPA Receptor; Excitatory Postsynaptic Potential; Mutual Inhibition; AMPA Receptor Antagonist;

D O I：

10.1007/BF02462489

中图分类号：

学科分类号：

摘要：

The mutual effects of components of excitatory postsynaptic potentials (EPSP) induced by activation of glutamate receptors sensitive to α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) were studied on living slices of rat hippocampus. Evoked responses were recorded in the radial layer (stratum radialis) in field CA1 after stimulation of collateral-commissural fibers. The contribution of the NMDA component to the total EPSP was altered by extracellular application of solutions containing different concentrations of magnesium. At low magnesium concentrations, when both components made significant contributions to EPSP, inhibition of one of the components by application of antagonists of the appropriate receptors led to increases in the area of the other component. Thus, the total magnitude of pharmacologically isolated components were significantly greater than the control response (for example, at 0.1 mM magnesium, the sum of the components was 340 ± 120% of the control two-component EPSP (p < 0.01; N = 6). These results suggest that in controls, the AMPA and NMDA components of EPSP inhibit each other. The mutual inhibition of components may be an important factor affecting the conductivity and plastic properties of central glutamatergic synaptic pathways. © 1999 Kluwer Academic/Plenum Publishers.

引用

页码：719 / 725

页数：6

共 21 条

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