The emergence of Cryptococcus gattii in British Columbia and the Pacific Northwest

被引：79

作者：

Bartlett K.H. ^{[1
]}

Kidd S.E. ^{[1
]}

Kronstad J.W. ^{[1
]}

机构：

[1] The Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4

来源：

Current Infectious Disease Reports | 2008年 / 10卷 / 1期

基金：

加拿大健康研究院;

关键词：

West Nile Virus; British Columbia; Human Case; Cryptococcus Neoformans; Cryptococcosis;

D O I：

10.1007/s11908-008-0011-1

中图分类号：

学科分类号：

摘要：

An unprecedented emergence of cryptococcal infections in animals and otherwise healthy humans was recognized in 1999 on the east coast of Vancouver Island, British Columbia. Unexpectedly, these infections were caused by Cryptococcus gattii, a species closely related to the AIDS-associated fungal pathogen Cryptococcus neoformans. Human cases have continued over the past 8 years and now total approximately 170 with eight deaths. Extensive environmental sampling, coupled with detailed molecular typing of isolates, revealed areas of permanent and transient colonization with primarily three genotypes of the fungus. C. gattii numerous tree species. Importantly, there is solid evidence for human-mediated dispersal of the pathogen, and C. gattii has now been detected in the environment on the mainland of British Columbia and in the Pacific Northwest. Associated animal and human cases are now being reported and further spread of the pathogen may be inevitable. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：58 / 65

页数：7

共 48 条

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