The role of interleukin-6 in the failing heart

被引：12

作者：

Wollert K.C. ^{[1
]}

Drexler H. ^{[1
]}

机构：

[1] Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover

来源：

Heart Failure Reviews | 2001年 / 6卷 / 2期

关键词：

Cytokines; Gp130; Heart failure; Interleukin-6;

D O I：

10.1023/A:1011401825680

中图分类号：

学科分类号：

摘要：

Clinical studies have shown that circulating levels of interleukin (IL)-6 and other IL-6 related cytokines are increased in patients with congestive heart failure (CHF). Plasma IL-6 concentrations are related to decreasing functional status of the patient and provide important prognostic information. Experimental studies have produced compelling evidence that IL-6 and IL-6 related cytokines play a pivotal role in the regulation of cardiac myocyte hypertrophy and apoptosis. This review summarizes clinical and experimental data from this rapidly evolving field, which, taken together, strongly suggest that IL-6 and IL-6 related cytokines are intricately involved in the pathophysiology of the failing heart.

引用

页码：95 / 103

页数：8

共 63 条

[1] Hirano T., Taga T., Nakano N., Yasukawa K., Kashiwamura S., Shimizu K., Nakajima K., Pyun K.H., Kishimoto T., Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2), Proc Natl Acad Sci USA, 82, pp. 5490-5494, (1985)
[2] Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S., Nakajima K., Koyama K., Iwamatsu A., Tsunasawa S., Sakiyama F., Matsui H., Takahara Y., Taniguchi T., Kishimoto T., Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, Nature, 324, pp. 73-76, (1986)
[3] Kishimoto T., Akira S., Narazaki M., Taga T., Interleukin-6 family of cytokines and gp130, Blood, 86, pp. 1243-1254, (1995)
[4] Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M., Leary A.C., Sibley B., Clark S.C., Williams D.A., Yang Y.C., Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine, Proc Natl Acad Sci USA, 87, pp. 7512-7516, (1990)
[5] Gearing D.P., Gough N.M., King J.A., Hilton D.J., Nicola N.A., Simpson R.J., Nice E.C., Kelso A., Metcalf D., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF), EMBO J, 6, pp. 3995-4002, (1987)
[6] Malik N., Kallestad J.C., Gunderson N.L., Austin S.D., Neubauer M.G., Ochs V., Marquardt H., Zarling J.M., Shoyab M., Wei C.M., Linsley P.S., Rose T.M., Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M, Mol Cell Biol, 9, pp. 2847-2853, (1989)
[7] Stockli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Gotz R., Lindholm D., Thoenen H., Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor, Nature, 342, pp. 920-923, (1989)
[8] Pennica D., King K.L., Shaw K.J., Luis E., Rullamas J., Luoh S.M., Darbonne W.C., Knutzon D.S., Yen R., Chien K.R., Baker J.B., Wood W.I., Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy, Proc Natl Acad Sci USA, 92, pp. 1142-1146, (1995)
[9] Senaldi G., Varnum B.C., Sarmiento U., Starnes C., Lile J., Scully S., Guo J., Elliott G., McNinch J., Shaklee C.L., Freeman D., Manu F., Simonet W.S., Boone T., Chang M.S., Novel neurotropin-1/B cell-stimulating factor-3. A cytokine of the IL-6 family, Proc Natl Acad Sci USA, 96, pp. 11458-11463, (1999)
[10] Peters M., Jacobs S., Ehlers M., Vollmer P., Mullberg J., Wolf E., Brem G., Meyer Zum Buschenfelde K.H., Rose-John S., The function of the soluble interleukin 6 (IL-6) receptor in vivo. Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half life of IL-6, J Exp Med, 183, pp. 1399-1406, (1996)

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