A randomized multicenter study to determine the efficacy of activity restriction for preterm labor management in patients testing negative for fetal fibronectin

被引：27

作者：

Elliott J.P. ^{[1
]}

Miller H.S. ^{[2
,3
]}

Coleman S. ^{[4
]}

Rhea D. ^{[4
]}

Abril D. ^{[1
]}

Hallbauer K. ^{[3
]}

Istwan N.B. ^{[4
]}

Stanziano G.J. ^{[4
]}

机构：

[1] Phoenix Perinatal Associates, Obstetrix Medical Group of Arizona, Phoenix, AZ 85006

[2] Tucson Perinatal Associates, Obstetrix Medical Group of Arizona, Tucson, AZ

[3] University of Arizona, Tucson, AZ

[4] Matria Healthcare, Marietta, GA

来源：

Journal of Perinatology | 2005年 / 25卷 / 10期

关键词：

D O I：

10.1038/sj.jp.7211359

中图分类号：

学科分类号：

摘要：

Objective: To assess the impact of activity restriction (AR) on the incidence of preterm birth in women treated for preterm labor testing negative for fetal fibronectin (fFN). Study design: Women who were diagnosed with preterm labor and tocolyzed with magnesium sulfate were concurrently screened with fFN for the purpose of subsequent management. Included were consenting patients with negative fFN, gestational age 23 0/7-33 6/7 weeks, cervical dilation ≤3cm, and minimal vaginal bleeding. Patients were randomized to AR or no AR. Primary study outcome was incidence of preterm delivery and interval from randomization to delivery. Results: A total of 73 women with negative fFN were randomized (36 with AR, 37 without AR). The overall preterm birth rate was 40%, with 44.4% of patients with AR and 35.1% of patients without AR delivering preterm, p = 0.478. Conclusion: Maternal AR did not impact pregnancy outcome. The incidence of preterm birth in symptomatic women testing fFN negative was higher than previously reported. © 2005 Nature Publishing Group. All rights reserved.

引用

页码：626 / 630

页数：4

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