Hepatic acute-phase reaction in histamine-deficient gene targeted mice

被引：8

作者：

Donászi-Ivanov A. ^{[1
,3
]}

Scharek P. ^{[1
]}

Falus A. ^{[1
,2
]}

Fülöp A.K. ^{[1
]}

机构：

[1] Dept. of Genet., Cell/Immunobiol., Semmelweis University, H-1445 Budapest

[2] Molecular Immunology Research Group, Hungarian Academy of Sciences, Budapest

[3] C.E. Schmidt College of Science, Florida Atlantic University, Boca Raton, FL

来源：

InflammoPharmacology | 2004年 / 12卷 / 1期

关键词：

Cytokines; Gene knock-out; Hepatic acute-phase proteins; Histamine; Systemic acute-phase reaction;

D O I：

10.1163/156856004773121365

中图分类号：

学科分类号：

摘要：

Histamine is a versatile mediator that, according to in vitro studies, affects the synthesis of inflammatory cytokines and acute-phase proteins. The histidine-decarboxylase knockout (HDC-/-) mouse is a model of in vivo investigation of the physiologic and metabolic integration of the acute-phase response. These mice do not synthesise histamine and feeding them with histamine-poor diet they are almost completely histamine-deficient. We compared the serum concentrations of representatives of acute-phase plasma proteins, as well as the levels IL-6 and IL-1α in wild type and HDC-/- mice during local (turpentine-induced) or systemic (LPS-induced) inflammation. The level of some acute-phase proteins significantly differed in wild-type and HDC-/- mice while others remained unaffected. The IL-6 levels are also differ in the wild-type and histamine-deficient animals, suggesting that the effect of histamine is attained through IL-6, although direct effect is not disclosed yet.

引用

页码：47 / 55

页数：8

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