Celiac disease: Is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances

被引：6

作者：

Gadewar S. ^{[1
]}

Fasano A. ^{[1
]}

机构：

[1] Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201

来源：

Current Gastroenterology Reports | 2005年 / 7卷 / 6期

关键词：

Celiac Disease; Coeliac Disease; Capsule Endoscopy; Villous Atrophy; Celiac Disease Patient;

D O I：

10.1007/s11894-005-0076-z

中图分类号：

学科分类号：

摘要：

Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is a protein component in wheat and other cereals, such as rye and barley. At present, the only available treatment is a strict gluten-free diet. Recent advances have increased our understanding of the molecular basis for this disorder. The past decade has seen new scientific developments in this disease and led to the formulation of new concepts of pathophysiology and clinical manifestations. There are several targets for new treatments. This article briefly summarizes the National Institutes of Health Consensus Statement and gives an overview of new findings in recent years and of future therapeutic options for CD. Copyright © 2005 by Current Science Inc.

引用

页码：455 / 461

页数：6

共 43 条

[1]

Bevan S., Popat S., Braegger C.P., Et al., Contribution of the MHC region to the familial risk of coeliac disease, J Med Genet, 36, pp. 687-690, (1999)

[2]

Hogberg L., Falth-Magnusson K., Grodzinsky E., Et al., Familial prevalence of coeliac disease: A twenty-year follow-up study, Scand J Gastroenterol, 38, pp. 61-65, (2003)

[3]

Murray J.A., Van Dyke C., Plevak M.F., Et al., Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001, Clin Gastroenterol Hepatol, 1, pp. 19-27, (2003)

[4]

Iughetti L., Bulgarelli S., Forese S., Et al., Endocrine aspects of coeliac disease, J Pediatr Endocrinol Metab, 16, pp. 805-818, (2003)

[5]

Queiroz M.S., Nery M., Cancado E.L., Et al., Prevalence of celiac disease in Brazilian children of short stature, Braz J Med Biol Res, 37, pp. 55-60, (2004)

[6]

Cacciari E., Salardi S., Lazzari R., Et al., Short stature and celiac disease: A relationship to consider even in patients with no gastrointestinal tract symptoms, J Pediatr, 103, pp. 708-711, (1983)

[7]

Locuratolo N., Pugliese G., Pricci F., Et al., The circulating insulin-like growth factor system in children with coeliac disease: An additional marker for disease activity, Diabetes Metab Res Rev, 15, pp. 254-260, (1999)

[8]

Peracchi M., Molteni N., Cantalamessa L., Et al., Abnormal growth hormone responsiveness to stimuli in women with active celiac sprue, Am J Gastroenterol, 87, pp. 580-583, (1992)

[9]

Stenson W.F., Newberry R., Lorenz R., Et al., Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis, Arch Intern Med, 165, pp. 393-399, (2005)

[10]

Mora S., Barera G., Ricotti A., Et al., Reversal of low bone density with a gluten-free diet in children and adolescents with celiac disease, Am J Clin Nutr, 67, pp. 477-481, (1998)

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