The use of microbubbles to target drug delivery

被引：155

作者：

Tsutsui J.M. ^{[1
]}

Xie F. ^{[1
]}

Porter R.T. ^{[1
]}

机构：

[1] Department of Internal Medicine, Section of Cardiology, Univ. of Nebraska Medical Center, Omaha, NE

来源：

Cardiovascular Ultrasound | / 2卷 / 1期

关键词：

Acoustic Power; Microbubble Destruction; Peak Negative Pressure; High Mechanical Index; Microbubble Shell;

D O I：

10.1186/1476-7120-2-23

中图分类号：

学科分类号：

摘要：

Ultrasound-mediated microbubbles destruction has been proposed as an innovative method for noninvasive delivering of drugs and genes to different tissues. Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials. Furthermore, the ability of albumin-coated microbubbles to adhere to vascular regions with glycocalix damage or endothelial dysfunction is another possible mechanism to deliver drugs even in the absence of ultrasound. This review focuses on the characteristics of microbubbles that give them therapeutic properties and some important aspects of ultrasound parameters that are known to influence microbubblemediated drug delivery. In addition, current studies involving this novel therapeutical application of microbubbles will be discussed. © 2004 Tsutsui et al; licensee BioMed Central Ltd.

引用

共 39 条

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