Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord

被引：6

作者：

Xu C.-X. ^{[1
]}

Liu H.-T. ^{[1
]}

Wang J. ^{[1
]}

机构：

[1] Institute of Healthy and Environmental Medicine, Academy of Military Medical Sciences

来源：

Neuroscience Bulletin | 2008年 / 24卷 / 1期

关键词：

5-hydroxytryptamine; Exercise-induced fatigue; Immunohistochemistry; Spinal cord; Tryptophan hydroxylase; Ventral horn;

D O I：

10.1007/s12264-008-1031-4

中图分类号：

学科分类号：

摘要：

Objective: To investigate changes of 5-hydroxytryptamine (5-HT) and its synthesis rate-limiting enzyme tryptophan hydroxylase (TPH) in the ventral horn of spinal cord after exercise-induced fatigue, and to further discuss the mechanism of exercise-induced central fatigue at spinal level. Methods: Sixteen healthy adult Wistar rats were randomly divided into 2 groups: exercise-induced fatigue group and control group. Immunohistochemical staining for 5-HT and TPH in the ventral horn were performed and analysized quantitatively. The mean optic densities of 5-HT and TPH positive fibers or terminals were measured by computerized image analyzer. Results: Both 5-HT and TPH positive fibers/terminals decreased in the exercise-induced fatigue group. The immunohistochemical staining was weaker and the mean optic densities decreased obviously in the fatigue group compared with those in the control group (P < 0.05). Conclusion: 5-HT and TPH in the ventral horn of spinal cord might be involved in exercise-induced fatigue. © 2008 Shanghai Institutes for Biological Sciences.

引用

页码：29 / 33

页数：4

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