Antioxidants and CVD in diabetes: Where do we stand now?

被引：38

作者：

Yim S. ^{[1
]}

Malhotra A. ^{[1
]}

Veves A. ^{[1
]}

机构：

[1] Microcirculation Laboratory, Palmer 321A, Beth Israel Deaconess Medical Center, Boston, MA 02215, One Deaconess Road

来源：

Current Diabetes Reports | 2007年 / 7卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Endothelial Dysfunction; Physiol Heart Circ; Polyol Pathway; Benfotiamine; Smooth Muscle Cell Growth;

D O I：

10.1007/s11892-007-0003-9

中图分类号：

学科分类号：

摘要：

Diabetes is an oxidative stress disorder as a result of both hyperglycemia and increased levels of free fatty acids. Oxidative stress has been implicated in the pathogenesis of diabetes-related complications, and treatment with antioxidants seemed to be a promising therapeutic option. Although animal studies and preliminary human studies were initially encouraging, subsequent human studies have failed to show a clear benefit of antioxidants, whereas some studies have even suggested that they can be potentially harmful. Therefore, treatment with antioxidants cannot be currently recommended as a therapeutic option. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：8 / 13

页数：5

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