A phase II study of capecitabine plus oxaliplatin (XELOX)A new first-line option in metastatic colorectal cancer

被引:27
作者
Thomas Makatsoris
Haralabos P. Kalofonos
Gerasimos Aravantinos
Christos Papadimitriou
Efstathios Kastritis
Sotirios K. Rigatos
Nikolaos Xiros
Theodore Petsas
Theofanis Economopoulos
Athanassios K. Sakadamis
George Fountzilas
机构
[1] Hellenic Cooperative Oncology Group (HECOG),Division of Oncology, Department of Medicine
[2] Data Office,undefined
[3] University Hospital,undefined
[4] Patras Medical School,undefined
来源
International Journal of Gastrointestinal Cancer | 2005年 / 35卷 / 2期
关键词
Metastatic colorectal cancer; oxaliplatin; capecitabine; XELOX;
D O I
10.1385/IJGC:35:2:103
中图分类号
学科分类号
摘要
Background: Capecitabine and oxaliplatin are both effective and well-tolerated monotherapies for the treatment of advanced colorectal cancer (CRC). Oxaliplatin has also been shown to be very effective when combined with 5-FU/LV in the first-line setting.
引用
收藏
页码:103 / 109
页数:6
相关论文
共 66 条
[1]  
Schmoll H-J(1998)Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer J Clin Oncol 16 301-308
[2]  
Büchele T(1992)Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate J Clin Oncol 10 896-903
[3]  
Grothey A(1999)Where do we stand with 5-fluorouracil? Semin Oncol 26 589-605
[4]  
Dempke W(1999)Survival impact of chemotherapy in patients with colorectal metastases confined to the liver: are-analysis of 1458 non-operable patients randomised in 22 trials and 4 meta-analyses. Meta-Analysis Group in Cancer Ann Oncol 10 1317-1320
[5]  
Thirion P(1998)Oral fluoropyrimidines in the treatment of colorectal cancer Eur J Cancer 34 1509-1513
[6]  
Wolmark N(1998)The oral fluorouracil prodrugs Oncology (Huntingt) 12 48-51
[7]  
Haddad E(1998)Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue Eur J Cancer 34 1274-1281
[8]  
Buyse M(2000)Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients Cancer Chemother Pharmacol 45 291-297
[9]  
Piedbois P(2002)Capecitabine as first-line treatment in colorectal cancer. Pooled data from two large, phase III trials Eur J Cancer 38 15-20
[10]  
Meropol NJ(2002)First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin Ann Oncol 13 566-575