Predicting the performance of immobilized enzyme reactors using reversible Michaelis-Menten kinetics

被引:12
作者
Abu-Reesh I.M. [1 ]
机构
[1] Chemical Engineering Department, University of Jordan
关键词
Equilibrium Constant; Peclet Number; Plug Flow; Reactor Performance; Plug Flow Reactor;
D O I
10.1007/PL00008960
中图分类号
学科分类号
摘要
A general mathematical model is developed in the present work for predicting the steady state performance of immobilized enzyme reactor performing reversible Michaelis - Menten kinetics. The model takes into account the effect of external diffusional limitations, the axial dispersion and the equilibrium constant on reactor performance quantified as relative substrate conversion and yield. The performance of reactor is characterized using the dimensionless parameters of Damkohler number, Stanton number, Peclet number, the equilibrium constant and the dimensionless input substrate concentration. The reactor performance is described for the two extreme cases of plug flow reactor (PFR) and continuous stirred tank reactor (CSTR) in addition to the intermediate case of dispersed plug flow reactor (DPFR). The performance of reactor is compared for the two cases of zero order and reversible first order kinetics.
引用
收藏
页码:131 / 137
页数:6
相关论文
共 12 条
[1]  
Kobayashi T., Moo-Young M., Backmixing and mass transfer in the design of immobilized-enzyme reactors, Biotechnol. Bioeng., 13, pp. 893-910, (1971)
[2]  
Lortie R., Pelletier D., Comparison between dispersion and plug flow models for fixed-bed enzyme reactors, AIChE J., 38, pp. 1477-1480, (1992)
[3]  
Ching C.B., Chu K.H., Modeling of a fixed bed and a fluidized bed immobilized enzyme reactor, Appl. Microbiol. Biotechnol., 29, pp. 316-322, (1988)
[4]  
Ching C.B., Ho Y.Y., Flow dynamics of immobilized enzyme reactors, Appl. Microbiol. Biotechnol., 20, pp. 303-309, (1984)
[5]  
Vasic-Racki D., Pavlovic N., Cizmek S., Drazic M., Husadzic B., Development of reactor model for glucose isomerization catalyzed by whole-cell immobilized glucose isomerase, Bioprocess Eng., 7, pp. 183-187, (1991)
[6]  
Park Y.H., Han M.H., Rhee H.K., Effect of external mass transfer in a packed bed reactor system for a reversible enzyme reaction, J. Chem. Technol. Biotechnol., 34 B, pp. 57-69, (1984)
[7]  
Lortie R., Evaluation of the performance of immobilized enzyme reactors with Michaelis-Menten kinetics, J. Chem. Technol. Biotechnol., 60, pp. 189-193, (1994)
[8]  
Van Tilburg R., Enzymatic isomerization of corn starch-based glucose syrups, Starch Conversion Technology, (1985)
[9]  
Levenspiel O., Chemical Reaction Engineering, (1972)
[10]  
Danckwerts P.V., Continuous flow systems, Distribution of residence times, Chem. Eng. Sci., 2, 1, pp. 1-18, (1953)