Predictive value of human chorionic gonadotropin β-hCG in early pregnancy after assisted conception

被引:7
作者
Zayed F. [1 ]
Ghazawi I. [2 ]
Francis L. [1 ]
Alchalabi H. [1 ]
机构
[1] Department of Obstetrics and Gynaecology, Jordan University of Science and Technology, Amman-11196
[2] Al-Amal Hospital, Amman
关键词
Assisted conception; Human chorionic Gonadotrophin (β-hCG); Pregnancy outcome; SIUI/SIVF;
D O I
10.1007/s004040000097
中图分类号
学科分类号
摘要
Objective: This study was designed to evaluate the predictive value of β-hCG levels in predicting the pregnancy outcome. Methods: A retrospective analysis was done on 423 pregnant patients following assisted conception (stimulated in vitro fertilization [SIVF] and stimulated intra uterine insemination [SIUI]). These were monitored with plasma β-hCG on day +18 post hCG injection. Ongoing pregnancy was defined as greater than 20 weeks. Results: Four hundred twenty three patients had a positive serum quantitative β-hCG level 18 days post hCG injection. Of these 321 (75.9%) were ongoing pregnancies. The spontaneous miscarriages were 98 (23.2%), and four ectopic pregnancies were recorded. Of the successful pregnancies, 279 were single births, and 42 were multiple births (15.1%), that is either twins (31) or triplets (11). Tables were calculated to help predicting the pregnancy outcome. Conclusions: It can be shown that +18 levels of β-hCG in cases of assisted conception are useful and provide predictive information concerning pregnancy outcome which should be helpful for the staff and the infertility patients.
引用
收藏
页码:7 / 10
页数:3
相关论文
共 25 条
[1]  
Aboud E., Chaliha C., Nine year survey of 138 ectopic pregnancies, Arch Gynecol Obstet, 261, pp. 83-87, (1998)
[2]  
Batzer F.R., Schlaff S., Goldfarb A.F., Corson S.L., Serial beta-subunit human chorionic gonadotropin doubling time as a prognosticcation of pregnancy outcome in an infertile population, Fertil Steril, 35, pp. 307-312, (1981)
[3]  
Braunstein G.D., Grodin J.M., Vaitukaitis J., Ross G.T., Secretory rates of human chorionic gonadotropin by normal trophoblast, Am J Obstet Gynecol, 115, pp. 447-450, (1973)
[4]  
Braunstein G.D., Rasor J., Adler D., Danzer H., Wade M.E., Serum human chorionic gonadotropin levels through normal pregnancy, Am J Obstet Gynecol, 126, pp. 678-681, (1976)
[5]  
Braunstein G.D., Karow W.G., Gentry W.C., Rasor J., Wade M.E., First trimester chorionic gonadotropin measurements as an aid in the diagnosis of early pregnancy disorders, Am J Obstet Gynecol, 131, pp. 25-32, (1978)
[6]  
Chen C.D., Ho H.N., Wu M.Y., Chao K.H., Chen S.U., Yang Y.S., Paired human chorionic gonadotrophin determinations for the prediction of pregnancy outcome in assisted reproduction, Hum Reprod, 12, pp. 2538-2541, (1997)
[7]  
Cole L.A., Restrepo-Candelo H., Lavy G., DeCerney A., hCG free beta-subunit an early marker of outcome of in vitro fertilisation clinical pregnancies, J Clin Endocrinol Metab, 64, pp. 1328-1330, (1987)
[8]  
Confino E., Demir R.H., Friberg J., Gleicher N., The predictive value of hCG β-subunit levels in pregnancies achieved by in vitro fertilization and embryo transfer: An international collaborative study, Fertil Steril, 45, pp. 526-531, (1986)
[9]  
Dodson W.C., Tyrey L., Haney A.F., Serum human chorionic gonadotropin concentration for predicting multiple gestation in pregnancies conceived with superovulation and intrauterine insemination, J Reprod Med, 36, pp. 651-654, (1991)
[10]  
Drugan A., O'Brien J.E., Dvorin E., Krivchenia E.L., Johnson M.P., Sokol R.J., Evans M.I., Multiple marker screening in multifetal gestations: Failure of predict adverse pregnancy outcomes, Fetal Diagn Ther, 11, pp. 16-19, (1996)