Health-related quality of life is related to COPD disease severity

被引：234

作者：

Ståhl E. ^{[1
,2
]}

Lindberg A. ^{[3
,4
]}

Jansson S.-A. ^{[3
,5
]}

Rönmark E. ^{[3
,5
]}

Svensson K. ^{[2
]}

Andersson F. ^{[2
]}

Löfdahl C.-G. ^{[1
]}

Lundbäck B. ^{[3
,5
]}

机构：

[1] Department of Respiratory Medicine and Allergology, University Hospital

[2] AstraZeneca RandD Lund

[3] OLIN Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten

[4] Department of Respiratory Medicine and Allergy, University Hospital

[5] Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institute

来源：

Health and Quality of Life Outcomes | / 3卷 / 1期

关键词：

COPD; Disease severity; Epidemiological; Global Initiative for Chronic Obstructive Lung Disease (GOLD); Health-related quality of life; St George's Respiratory Questionnaire (SGRQ);

D O I：

10.1186/1477-7525-3-56

中图分类号：

学科分类号：

摘要：

Background: The aim of this study was to evaluate the association between health-related quality of life (HRQL) and disease severity using lung function measures. Methods: A survey was performed in subjects with COPD in Sweden. 168 subjects (70 women, mean age 64.3 years) completed the generic HRQL questionnaire, the Short Form 36 (SF-36), the disease-specific HRQL questionnaire; the St George's Respiratory Questionnaire (SGRQ), and the utility measure, the EQ-5D. The subjects were divided into four severity groups according to FEV1 per cent of predicted normal using two clinical guidelines: GOLD and BTS. Age, gender, smoking status and socio-economic group were regarded as confounders. Results: The COPD severity grades affected the SGRQ Total scores, varying from 25 to 53 (GOLD p = 0.0005) and from 25 to 45 (BTS p = 0.0023). The scores for SF-36 Physical were significantly associated with COPD severity (GOLD p = 0.0059, BTS p = 0.032). No significant association were noticed for the SF-36, Mental Component Summary scores and COPD severity. Scores for EQ-5D VAS varied from 73 to 37 (GOLD I-IV p = 0.0001) and from 73 to 50 (BTS 0-III p = 0.0007). The SGRQ Total score was significant between age groups (p = 0.0047). No significant differences in HRQL with regard to gender, smoking status or socio-economic group were noticed. Conclusion: The results show that HRQL in COPD deteriorates with disease severity and with age. These data show a relationship between HRQL and disease severity obtained by lung function. © 2005 Ståhl et al; licensee BioMed Central Ltd.

引用

页数：8

共 32 条

[1]

Vollmer W.M., Osborne M.L., Buist A.S., 20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO, American Journal of Respiratory & Critical Care Medicine, 157, pp. 1079-1084, (1998)

[2]

Pauwels R.A., Buist A.S., Calverley P.M.A., Jenkins C.R., Hurd S.S., Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI and WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD): Executive summary, Respiratory Care, 46, pp. 798-825, (2001)

[3]

BTS: BTS guidelines for the management of chronic obstructive pulmonary disease, Thorax, 52, (1997)

[4]

Ray D., Abel R., Selvaraj K.G., A 5-yr prospective epidemiological study of chronic obstructive pulmonary disease in rural south India, Indian Journal of Medical Research, 101, pp. 238-244, (1995)

[5]

Renwick D.S., Connolly M.J., Prevalence and treatment of chronic airways obstruction in adults over the age of 45, Thorax, 51, pp. 164-168, (1996)

[6]

Mannino D.M., Gagnon R.C., Petty T.L., Lydick E., Obstructive lung disease and low lung function in adults in the United States - Data from the National Health and Nutrition Examination Survey, 1988-1994, Arch. Intern. Med., 160, pp. 1683-1689, (2000)

[7]

Sobradillo V., Miravitlles M., Jimenez C.A., Gabriel R., Viejo J.L., Masa J.F., Fernandez-Fau L., Villasante C., Epidemiological study of chronic obstructive pulmonary disease in Spain (IBERPOC): Prevalence of chronic respiratory symptoms and airflow limitation, Arch. Bronconeumol., 35, pp. 159-166, (1999)

[8]

Lundback B., Lindberg A., Lindstrom M., Ronmark E., Jonsson A.C., Jonsson E., Larsson L.G., Andersson S., Sandstrom T., Larsson K., Not 15 but 50% of smokers develop COPD? Report from the Obstructive Lung Disease in Northern Sweden Studies, Respiratory Medicine, 97, pp. 115-122, (2003)

[9]

Lindstrom M., Jonsson E., Larsson K., Lundback B., Underdiagnosis of chronic obstructive pulmonary disease in Northern Sweden, Int. J. Tuberc. Lung Dis., 6, pp. 76-84, (2002)

[10]

Tirimanna P.R.S., van Schayck C.P., den Otter J.J., van Weel C., van Herwaarden C.L.A., van den Boom G., van Grunsven P.M., van den Bosch W.J.H.M., Prevalence of asthma and COPD in general practice in 1992: Has it changed since 1977?, Br. J. Gen. Pract., 46, pp. 277-281, (1996)

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