Molecular genetics of Alzheimer's disease

被引：51

作者：

Pastor P. ^{[1
]}

Goate A.M. ^{[1
]}

机构：

[1] Department of Psychiatry, Washington Univ. School of Medicine, St. Louis, MO 63110

来源：

Current Psychiatry Reports | 2004年 / 6卷 / 2期

关键词：

Cerebral Amyloid Angiopathy; Neuritic Plaque; Amyloid Protein Precursor Gene; Hereditary Cerebral Hemorrhage; Familial Early Onset Alzheimer Disease;

D O I：

10.1007/s11920-004-0052-6

中图分类号：

学科分类号：

摘要：

Alzheimer disease (AD) is the most common cause of dementia. In the past decade, many advances in the understanding of the etiology of AD have been reported. Familial early onset AD is a heterogeneous disorder that can be caused by mutations in at least three different genes. Current studies are focused on identifying genetic risk factors for late onset AD. In this article, the authors will review the progress in understanding the pathogenic implications of the genes mutated in familial early onset AD and the mapping studies to identify additional genes involved in late-onset AD. Copyright © 2004 by Current Science Inc.

引用

页码：125 / 133

页数：8

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