The need to reform our assessment of evidence from clinical trials: A commentary

被引：21

作者：

Bagshaw S.M. ^{[1
]}

Bellomo R. ^{[2
,3
]}

机构：

[1] Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, AB

[2] Department of Intensive Care, Austin Hospital, Melbourne, VIC

[3] Australian and New Zealand Intensive Care Research Centre, Monash University, School of Epidemiology and Preventive Medicine, Melbourne, VIC

来源：

Philosophy, Ethics, and Humanities in Medicine | / 3卷 / 1期

关键词：

Single Centre Study; Continuous Renal Replacement Therapy; Biological Plausibility; Massive Pulmonary Embolism; Medical Emergency Team;

D O I：

10.1186/1747-5341-3-23

中图分类号：

学科分类号：

摘要：

The ideology of evidence-base medicine (EBM) has dramatically altered the way we think, conceptualize, philosophize and practice medicine. One of its major pillars is the appraisal and classification of evidence. Although important and beneficial, this process currently lacks detail and is in need of reform. In particular, it largely focuses on three key dimensions (design, [type I] alpha error and beta [type II] error) to grade the quality of evidence and often omits other crucial aspects of evidence such as biological plausibility, reproducibility, generalizability, temporality, consistency and coherence. It also over-values the randomized trial and meta-analytical techniques, discounts the biasing effect of single centre execution and gives insufficient weight to large and detailed observational studies. Unless these aspects are progressively included into systems for grading, evaluating and classifying evidence and duly empirically assessed (according to the EBM paradigm), the EBM process and movement will remain open to criticism of being more evidence-biased than evidence-based. "All scientific work is incomplete - whether it be observational or experimental. All scientific work is liable to be upset or modified by advancing knowledge. That does not confer upon us a freedom to ignore the knowledge we already have, or to postpone the action that it appears to demand at a given time". © 2008 Bagshaw and Bellomo; licensee BioMed Central Ltd.

引用

共 63 条

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