Impaired leptin activity in New Zealand Obese mice: model of angiogenesis

被引：3

作者：

Lukasz Wator

Urszula Razny

Adriana Balwierz

Anna Polus

Hans G. Joost

Grzegorz Dyduch

Romana Tomaszewska

Aldona Dembinska-Kiec

机构：

[1] Jagiellonian University Medical College,Department of Clinical Biochemistry

[2] Jagiellonian University Medical College,Department of Pathomorphology

[3] German Institute of Human Nutrition,undefined

来源：

Genes & Nutrition | 2008年 / 3卷

关键词：

CD31 PECAM1; Leptin; Leptin receptor; NZO; Obesity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Leptin is prompt to drive angiogenesis, effecting proper vascularisation. Tissue remodeling (including adipose organ) is associated with the angiogenic response. The aim of this study was to investigate the effect of hyperleptinemia on angiogenesis in subcutaneous (s.c.) in vivo matrigel model in mice on a high fat (HF) diet. HF promoted adipose tissue accumulation and biochemical changes resembling metabolic syndrome. However, the impact of this dietary treatment on angiogenesis, measured in s.c. matrigel model was not significant. Changes in leptin concentration were not accompanied by significant angiogenic response. This lack of leptin activity and impaired signal transduction at the molecular level suggests malfunction of the leptin receptor in NZO mice.

引用

页码：177 / 180

页数：3

共 90 条

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