Review of Osteosarcoma and Current Management

被引：346

作者：

Durfee R.A. ^{[1
]}

Mohammed M. ^{[1
]}

Luu H.H. ^{[1
]}

机构：

[1] Department of Orthopaedic Surgery and Rehabilitation, University of Chicago, Chicago, IL

来源：

Rheumatology and Therapy | 2016年 / 3卷 / 2期

关键词：

Limb preservation surgery; Osteosarcoma; Review; Targeted therapy;

D O I：

10.1007/s40744-016-0046-y

中图分类号：

学科分类号：

摘要：

Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteosarcoma will be highlighted. Additionally, the clinical diagnosis of osteosarcoma will be discussed, as well as contemporary chemotherapeutic and surgical management of this tumor. Finally, the review will discuss some of the novel approaches to treating this disease. © 2016, The Author(s).

引用

页码：221 / 243

页数：22

共 137 条

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