Protocol of radiotherapy for glioblastoma according to the expression of HIF-1

被引：48

作者：

Irie N. ^{[1
]}

Matsuo T. ^{[1
]}

Nagata I. ^{[1
]}

机构：

[1] Department of Neurosurgery, Nagasaki University Hospital, Nagasaki 852-8501

来源：

Brain Tumor Pathology | 2004年 / 21卷 / 1期

关键词：

Glioblastoma; Hypoxia-inducible factor-1; Intratumoral hypoxia; Stereotactic radiosurgery;

D O I：

10.1007/BF02482169

中图分类号：

学科分类号：

摘要：

Hypoxia is a common feature of many malignant neoplasms and has been identified as a major reason for the radioresistance of malignant tumor tissue. On the other hand, the transcription factor hypoxia-inducible factor-1 (HIF-1) has attracted attention because it is rapidly expressed when tissue oxygen tension is reduced, thus playing the role of a hypoxic sensor. We investigated whether the level of HIF-1 expression in glioblastoma (GBM) could be an indicator in a protocol for postoperative radiotherapy. We immunohistologically evaluated the level of HIF-1 expression in 60 pathologically diagnosed GBMs. HIF-1 expression was positive in all tumors. The progression-free survival of the group receiving only conventional radiotherapy after surgery differed significantly according to the level of HIF-1 expression. The results of this study suggest that the HIF-1 expression level can be an indicator of tumor radioresistance, and that prior knowledge of the HIF-1 expression level allows the formulation of a protocol for post-operative radiotherapy.

引用

页码：1 / 6

页数：5

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