ADHD genetics: 2007 update

被引：28

作者：

Elia J. ^{[1
]}

Devoto M. ^{[1
]}

机构：

[1] The Children's Hospital of Philadelphia, Science Center, Philadelphia, PA 19104-6209

来源：

Current Psychiatry Reports | 2007年 / 9卷 / 5期

关键词：

ADHD Symptom; Acad Child Adolesc Psychiatry; ADHD Subtype; Prenatal Nicotine Exposure; Dopamine Transporter Gene;

D O I：

10.1007/s11920-007-0057-z

中图分类号：

学科分类号：

摘要：

Attention-deficit/hyperactivity disorder (ADHD) is highly heritable. Confirmed association has been reported for several candidate genes, including DAT1, DRD4, SNAP-25, DRD5, 5HTT, HTR1B, and DBH; however, these confer relatively small risk. Family-based linkage studies have identified a number of chromosomal regions containing potential ADHD predisposing loci, some overlapping in two or more studies, including 5p, 6q, 7p, 11q, 12q, and 17p. New large-scale studies that apply recent technological advances to perform high-density genotyping of the entire genome, in combination with information on the haplotype structure of the human genome, now allow testing of single-nucleotide polymorphism association with disease phenotype without any a priori hypothesis. They may contribute further to our understanding of the genetic factors involved in ADHD. The heterogeneous complex ADHD phenotype, as well as epigenetic factors may be contributing to the challenge of genetic studies. Samples that include limited age ranges may have better success at uncovering genes whose expression is limited to specific developmental stages. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：434 / 439

页数：5

共 50 条

[1]

Faraone S.V., Biederman J., Chen W.J., Et al., Genetic heterogeneity in attention-deficit hyperactivity disorder (ADHD): Gender, psychiatric comorbidity, and maternal ADHD, J Abnorm Psychol, 104, pp. 334-345, (1995)

[2]

Sprich S., Biederman J., Crawford M.H., Et al., Adoptive and biological families of children and adolescents with ADHD, J Am Acad Child Adolesc Psychiatry, 39, pp. 1432-1437, (2000)

[3]

Faraone S.V., Perlis R.H., Doyle A.E., Et al., Molecular genetics of attention-deficit/hyperactivity disorder, Biol Psychiatry, 57, pp. 1313-1323, (2005)

[4]

Fisher S.E., Francks C., McCracken J.T., Et al., A genomewide scan for loci involved in attention-deficit/hyperactivity disorder, Am J Hum Genet, 70, pp. 1183-1196, (2002)

[5]

Smalley S., Kustanovich V., Minassian S.L., Et al., Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism, Am J Hum Genet, 71, pp. 959-963, (2002)

[6]

Ogdie M.N., Macphie I.L., Minassian S.L., Et al., A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: Suggestive linkage on 17p11, Am J Hum Genet, 72, pp. 1268-1279, (2003)

[7]

Ogdie M.N., Fisher S.E., Yang M., Et al., Attention deficit hyperactivity disorder: Fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11, Am J Hum Genet, 75, pp. 661-668, (2004)

[8]

Bakker S.C., van der Meulen E.M., Buitelaar J.K., Et al., A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: Suggestive evidence for linkage on chromosomes 7p and 15q, Am J Hum Genet, 72, pp. 1251-1260, (2003)

[9]

Hebebrand J., Dempfle A., Saar K., Et al., A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs, Mol Psychiatry, 11, pp. 196-205, (2006)

[10]

Arcos-Burgos M., Castellanos F.X., Pineda D., Et al., Attention-deficit/ hyperactivity disorder in a population isolate: Linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11, Am J Hum Genet, 75, pp. 998-1014, (2004)

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