Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature

被引：21

作者：

Bhagavathi S. ^{[1
]}

Greiner T.C. ^{[2
]}

Kazmi S.A. ^{[2
]}

Fu K. ^{[2
]}

Sanger W.G. ^{[3
]}

Chan W.C. ^{[2
]}

机构：

[1] Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak

[2] Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Nebraska Medical Center, Omaha

[3] Department of Cytogenetic, University of Nebraska Medical Center, 983135, Nebraska Medical Center

来源：

Journal of Hematopathology | 2008年 / 1卷 / 2期

关键词：

Dura; FISH; Primary CNS.MALT lymphoma; T(1418).MALT1 translocation;

D O I：

10.1007/s12308-008-0005-9

中图分类号：

学科分类号：

摘要：

Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma involving brain, intraocular structures and spinal cord, without evidence of systemic disease. The majority of PCNSLs are diffuse large B-cell type. We encountered a rare case of primary dural marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) with extension into the brain in a 59-year-old man. A magnetic resonance imaging scan showed a 22-mm tumor located in the left posterior temporal lobe extending from the dura. Histopathology revealed a lymphoplasmacytic infiltration of the dura and the brain parenchyma in a perivascular pattern. Immunohistochemical and in situ hybridization studies showed a B-cell phenotype with kappa light chain restriction. Fluorescent in situ hybridization study showed a t(14;18)(q32; q21) with immunoglobulin heavy-chain/MALT1 fusion. The molecular study for immunoglobulin heavy-chain gene rearrangement by polymerase chain reaction showed a clonal gene rearrangement. © Springer-Verlag 2008.

引用

页码：131 / 137

页数：6

共 37 条

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