Morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats

被引：6

作者：

Gulyaev S.M. ^{[1
]}

Ubasheev I.O. ^{[1
]}

Kozhevnikova N.M. ^{[1
]}

机构：

[1] Department of Biologically Active Substances, Institute of General and Experimental Biology, Russian Academy of Sciences, Ulan-Ude

来源：

Neuroscience and Behavioral Physiology | 2008年 / 38卷 / 7期

关键词：

Brain; Cerebroprotective action; Ischemia; Lanthanum acetate;

D O I：

10.1007/s11055-008-9041-2

中图分类号：

学科分类号：

摘要：

The aim of the present work was to perform a morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats. Chronic ischemia was produced in Wistar rats (weighing 160-180 g) by ligation of both common carotid arteries. Ischemic lesions were corrected by intragastric lanthanum acetate (3 mg/kg per day) throughout the experimental period. Ischemic damage to the cortex was assessed morphometrically on histological sections stained by the Nissl method. Lanthanum acetate was found to suppress the development of ischemic neuron damage in the cerebral cortex, with reductions in the numbers of hyperchromic neurons, cells with focal chromatolysis, and ghost cells, as well as an increase in the number of normochromic cells as compared with controls. © Springer Science+Business Media, Inc. 2008.

引用

页码：747 / 750

页数：3

共 14 条

[1]

Avtandilov N.D., Medical Morphometry, (1990)

[2]

Berkhova O.A., Soroka V.R., The biological role of lanthanides, Usp. Sovrem. Biol., 90, 3-6, pp. 365-381, (1980)

[3]

Gusev E.I., Skvortsova V.I., Brain Ischemia, (2001)

[4]

Lakin G.F., Biometry, (1990)

[5]

Microscope Technology: A Handbook for Doctors and Laboratory Staff, (1996)

[6]

Plotnikov M.B., Vaizova O.E., Comparative analysis of two models of chronic cerebral ischemia in the rat, Pat. Fiziol., 2, pp. 59-60, (1994)

[7]

Plotnikov M.B., Logvinov S.V., Pugachenko N.V., Et al., The cerebroprotective effects of a mixture of diquercetin and ascorbic acid, Byull. Éksperim. Biol., 130, 11, pp. 543-547, (2000)

[8]

Plotnikova T.M., Bazhenova T.G., Plotnikova M.B., Saratikov A.S., Effects of cerebrocrast on the microcirculation in acute transient cerebral ischemia, Eksper. Klin. Farmakol., 58, 2, pp. 27-29, (1995)

[9]

Bickler P.E., Hansen B.M., Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: Role of ion channels and membrane damage, Brain Res., 665, 2, pp. 269-276, (1994)

[10]

Das T., Sharma A., Talucder G., Effects of lanthanum in cellular systems, Biol. Trace Elem. Res., 18, pp. 201-228, (1988)

← 1 2 →