Liver Biopsies in Patients with Lysosomal Storage Disease : Experience with Effective Sedation

被引：3

作者：

Grewal R.P. ^{[1
,2
,6
]}

Yu K.T. ^{[1
,3
]}

Barton N.W. ^{[1
]}

Parker R.I. ^{[4
]}

Di Bisceglie A.M. ^{[5
]}

机构：

[1] Devmtl. and Metab. Neurology Branch, Natl. Inst. Neurol. Disord. Stroke, NIH, Bethesda, MD

[2] Department of Neurology, USC School of Medicine, Los Angeles, CA

[3] Depts. of Pediatrics and Neurology, Harbor-UCLA Medical Center, Torrance, CA

[4] Hematology Service, CPD, NIH, Bethesda, MD

[5] Liver Disease Section, Natl. Inst. Diabet. Digest. K., NIH, Bethesda, MD

[6] SHS 172 MC, University Park Campus, USC, Los Angeles, CA 90089

来源：

The Indian Journal of Pediatrics | 1997年 / 64卷 / 6期

关键词：

Liver biopsy; Sedation; Type 1 Gaucher's disease;

D O I：

10.1007/BF02725518

中图分类号：

学科分类号：

摘要：

We prospectively applied a protocol used to sedate children who required a liver biopsy. Sixty liver biopsies were performed on thirty pediatric patients to assess the effects of treatment. Sixteen patients had Type 1 Gaucher's disease of which seven had a platelet count between 50-100,000/mm3. All seven had bleeding time performed and when indicated, intravenous DDAVP (1-deamino-8-D-arginine vasopressin) was used to improve hemostasis. Fourteen patients had Niemann-Pick disease type C of which eight were significantly demented and uncooperative. Before liver biopsy, all patients were sedated with the following regimen : oral chlorpromazine (1 mg/kg) followed one hour later by intravenous meperidine (1 mg/kg) and pentobarbital (maximum dosage 6 mg/kg) administered by slow intravenous injection. Liver biopsies were obtained safely on all patients. Only 1 patient (2%) developed a potentially serious complication : an obstructed airway which was readily corrected by simple repositioning. Transient less serious complications occurred in another 7 patients (12%). There was no long term sequalae of the biopsy procedures. Our study indicates that with appropriate patient selection, this sedation protocol may be useful in pediatric patients requiring a liver biopsy.

引用

页码：887 / 891

页数：4

共 10 条

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