Multidrug Resistance in Brain Tumors: Roles of the Blood–brain Barrier

被引：27

作者：

Anthony Régina

Michel Demeule

Alain Laplante

Julie Jodoin

Claude Dagenais

France Berthelet

Albert Moghrabi

Richard Béliveau

机构：

[1] Hôpital Sainte-Justine-Université du Québec à,Laboratoire de Médecine Moléculaire

[2] ôpital Notre-Dame,Département de Pathologie, H

来源：

Cancer and Metastasis Reviews | 2001年 / 20卷

关键词：

blood–brain barrier; brain tumors; multidrug resistance; P-glycoprotein; endothelial cells;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Malignant brain tumors and brain metastases present a formidable clinical challenge against which no significant advances have been made over the last decade. Multidrug resistance (MDR) is one of the main factors in the failure of chemotherapy against central nervous system tumors. The MDR1 gene encoding P-glycoprotein (P-gp), a drug efflux pump which plays a significant role in modulating MDR in a wide variety of human cancers, is highly expressed in the blood–brain barrier (BBB). The BBB controls central nervous system exposure to many endogenous and exogenous substances. The exact molecular mechanisms by which the BBB is involved in the resistance of brain tumors to chemotherapy remain to be identified.

引用

页码：13 / 25

页数：12

共 436 条

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